Cellular Impact of Penis Enlargement

Does Mechanical force start the production of cellular division? What determines the final size of the penis? Obviously compression eliminates the division of cells so how does expansion effect the cell? At one point, in any mans life, he will reach his maximum size (growth and development, not including volume i.e. weight gain). An interesting question is what accounts for the differences in similar organisms final size differences? Why does puberty stop and start at different times for each human?

Although , as men, our bio-chemistry is complex, the ability of morphogens to duplicate internal tissue and start cell growth is evidently an aftermath of the response they effect in cells and their ability to transport and apply properties. Are morphogens the determining factor in a tissues final size or are mechanical stresses applicable in continuing the growth process beyond the predetermined final size? Who, and what tells our tissue to stop growing?

Our cells contain information via D.N.A. and this information is definite, the cell has instructions and the R.N.A. (the facilitating portion of cell growth) follow out these instructions. When the completion of these instructions are implemented cellular growth, effectively, stops. How confusing is penis enlargement when a definite, predetermined cellular size is established and finalized?

Compression (a tissues normal or compressed state) acts as a kind of blockage to cellular growth. When expansion is present cells divide at accelerated levels in comparison to compressed cells/or tissue. Escalation in volume, particularly blood in PE, increases the total needs of the cell's and this increases the need for a greater membrane area. Just like a cell you can look at your penis as being a cellular being with internal structures held together by a membrane called the tunica and the skin. Once maximum capacity is met, and held for a period, the penis has little choice but to increase in size (or divide) This is pretty easy if cells act as any normal membrane and expand to accommodate increased volume. Hypothetically, expansion of the penis almost has to be initiated by reawakened morphogens and their contribution to tissue deformation.

If cells do not divide to accommodate increased size in PE they must act as an elastic solid of sorts. (see my thread on elastic theory) If a cell does not part from it's nucleus to increase membrane size it would need to stretch to accomplish this. Stretching a solid almost always leads to a total and permanent deformation of area. There is really no other option.

Bruce Edgar, a biologist from the Fred Hutchinson Cancer Research Center in Seattle comments on the similarity of the pair �Growth suppression by compression is a plausible and attractive idea, Although the underlying molecular mechanism hasn�t been identified, there are some candidates. When a disk cell encounters the morphogen, a protein called ?-catenin enters the cell�s nucleus to initiate the expression of proteins that forestall apoptosis and promote growth. Intriguingly, ?-catenin has another role. The cytoskeletons of neighboring cells link to each other though membrane-spanning proteins called cadherins. The molecule that mediates the link is ?-catenin. Edgar points out another line of suggestive evidence. The genes Lethal giant disks, Disks large, and Scribble form a complex involved in cell adhesion. �If you knock them out,� he says, �the epithelium becomes a blob that never stops growing.�

This is a very encouraging statement for the men who PE

Predetermined cell growth is, most likely, unchangeable through further cell division after it reaches maturity. Meaning, once the tissue has reached it's precogitated size it stops growing. If this is the case the only "real" method of penis enlargement is through the stretching of the mature cellular tissue with the contribution of morphogens. This brings the final question, Does a continued cycle of cellular expansion and accommodation give an infinite detail to the rather finite division of cells?