View Full Version : Supra's Growth Hormone Trials
Updated September 27, 2011
Well guys great new, I am back on HGH
I will give you all the details.
This is what I am taking
Norditropin 5mg/1.5ml
2iu's a day before working out.
Just started today will keep you posted.
I am doing HGH right now not IGF-1, do not be confused.
Faster and better Penis Enlargement (http://www.mattersofsize.com/forum/showthread.php?t=4904)
My freind to just HGH and gained 1" in about a 4 months with HGH, IGF-1LR3 is 10X stronger, more effective and longer lasting in your body than HGH
quijjiboo
02-23-04, 12:18 AM
Damn, I'm VERY interested in seeing how IGF-1 goes along with PE. I've heard guys on steroid forums say they've gained an inch or so from GH, and I have no doubts that IGF-1 would be better.
About the juice, I would say up the test to 300-400mg per week and use liquidex over clomid while on cycle, just my opinion. Even add an anabolic (maybe winny), you're going all out anyways rofl
Good luck!
9cyclops9
02-23-04, 12:20 AM
Be careful with that man. I don't want to see you mess up all your BE work!
John
Oh man, all this BE I do, and the IGF-1LR3 and the clomd, my balls are going to get even bigger, not to mention my dick.
Damn, I'm VERY interested in seeing how IGF-1 goes along with PE. I've heard guys on steroid forums say they've gained an inch or so from GH, and I have no doubts that IGF-1 would be better.
About the juice, I would say up the test to 300-400mg per week and use liquidex over clomid while on cycle, just my opinion. Even add an anabolic (maybe winny), you're going all out anyways rofl
Good luck!
What is liquidex? Liquid Clomid, casue that is what i am gong to use, its liquid, I drink it. Winnie HUH? Pill or injectable?
quijjiboo
02-23-04, 01:13 AM
What is liquidex? Liquid Clomid, casue that is what i am gong to use, its liquid, I drink it. Winnie HUH? Pill or injectable?
Liquidex is just the liquid form of Arimidex (liquid bit cheaper than the pill), which is an anti-aromatase, so it will block conversion of T into E. Clomid and Nolvadex are very similar drugs, which do not reduce blood E levels like Liquidex, but will block its effects at the receptors, so its as if there isn't any E there. (you prob know this already..) that's basically the difference.
About the Winny Im just talking out my ass, I would add an anabolic but you got your cycle laid out already... Winny might be a good complement to the test, I would use tren or deca but those are really harsh I know you had a rough cycle before so Winny would be a nice lighter anabolic to add
here's an awesome site that will give you profiles of all the drugs ive mentioned:
http://www.bodybuilding.com/fun/catsteroids.htm
btw: I dont recommend any drugs to anyone! :)
Winny, pill or injectable? Yea I had a rouch cycle before so I am staying away from the harsh stuff for sure Were can I get liqadex?
quijjiboo
02-23-04, 01:20 AM
Winny, pill or injectable? Yea I had a rouch cycle before so I am staying away from the harsh stuff for sure Were can I get liqadex?
Winny can be either, usually pill though.. Liquidex you can get legally in the States from liquid research products companies (I can't give you names though, do a search if you want it you'll find it easy)
I got one already, thanks. You dont think the clomd with the Ring of Power will do enough for the estrogen? Im not takin that much test.
quijjiboo
02-23-04, 01:29 AM
I got one already, thanks. You dont think the clomd with the Ring of Power will do enough for the estrogen? Im not takin that much test.
ya with 200mg/week you probably wouldn't need anything, but my choice would be to go with real low dose of liquidex, maybe .25mg/day to be safe.
I've gone up to 750mg/week test with dbol taking nothing! Everybodys different...
Metallikat
02-23-04, 01:48 AM
Winny can be either, usually pill though.. Liquidex you can get legally in the States from liquid research products companies (I can't give you names though, do a search if you want it you'll find it easy)
I wouldn't buy from LR if I was you. They just got busted.
quijjiboo
02-23-04, 01:53 AM
I wouldn't buy from LR if I was you. They just got busted.
really, I gotta check that out.. there's others..
I think with the the amount of IGF-1LR3 combined with everythign else I am taking My dick is going to get freaky big, I can just feel it. Im going to get this huge mushroom head like I have been working for and my forsking will restore a lot faster. And talk about some freaky length and girth comming, let me tell you.
Metallikat
02-23-04, 02:03 AM
Power Nutrition is still safe far as I know :cool:
quijjiboo
02-23-04, 03:02 AM
I think with the the amount of IGF-1LR3 combined with everythign else I am taking My dick is going to get freaky big, I can just feel it. Im going to get this huge mushroom head like I have been working for and my forsking will restore a lot faster. And talk about some freaky length and girth comming, let me tell you.
For the best information on 'recreational use' of IGF-1, check out www.animalkits.be
This forum is the most hardcore I've ever seen, the guys there know more about IGF-1 than scientists do serious, I like to think I know alot about bodybuilding but alotta that stuff is way over my head. If you're serious about using IGF-1, this should be one of your resources for info.
Gardenier90
02-23-04, 04:13 AM
Sounds interesting.
Hey I bought the arimidex (liquidex) And Cialis
You know that after your test-cycle your testosterone levels will crash and go below your normal levels for awhile? At least that's what i've read.
You know that after your test-cycle your testosterone levels will crash and go below your normal levels for awhile? At least that's what i've read.
Not with the clomid and Ring of Power and the Arimidex, it will not let it happend, no way in hell am i going to make that mistake again brotha!!
WideAwake
02-23-04, 10:01 AM
I am going to take the IGF-1 5 on 2 off 50mg's a day 4 weeks on and 4 weeks off
Testoterone Depot 200mg's a week
Liquidex (Arimidex) 1mg 3-5times a week
25mg Liguid Clomid when needed[/URL]
Supra, after all the trouble you've had in the past with steriods I'm surprised to see you including the test enthanate at 200mg/week.
What could be your reason for this?
You've already posted somewhere that your natural test levels come in around 900ng/dl...that's an amazingly high level of natty test for ANYONE!
200mg/week will supress your natural test production in as little as two weeks.
200mg/week will NOT bring you levels even near 900ng/dl.
So you're basically going to shut yourself down again and not even have the benefit of increasing your testosterone levels higher than they already are in your natural state.
Please understand that I'm a 35 year old guy with SEVERAL cycles under his belt and the blood work done both pre and post cycle to validate the info I've posted above.
The test depot will be a huge mistake. In my opinion all you should focus on is the IGF and than see how that goes. Than if you so wish, add in the other stuff on the next 4 week cycle to see if you notice any difference. Otherwise how can you give the IGF a fair shake?
Also - how are you injecting the IGF? Where? How often? Are you backfilling slin pins or other?
WA
I am going to be using the 2 Ring of Power, Clomid and Arimidex, my natraul test will actually go up not down, I am only going to take 200mg a week a small amount to the last time compared to 900mg i was taking.
THe IGF-1LR3 gets better and faster resutls from a steriod
I will be using insulen needles and shooting it the stomach or butt
WideAwake
02-23-04, 10:12 AM
I am going to be using the 2 Ring of Power, Clomid and Arimidex, my natraul test will actually go up not down, I am only going to take 200mg a week a small amount to the last time compared to 900mg i was taking.
THe IGF-1LR3 gets better and faster resutls from a steriod
I will be using insulen needles and shooting it the stomach or butt
I like the ROP myself so far, but I wouldn't bet it will maintain your natural endocrine system in light of adding exogenous amounts of test.
Clomid is great...as a SERM (selective Estrogen Receptor Modulator) but it will not help keep FSH from decreasing when you add test to your system, it'll help maintain a nice ratio of test to estrogen, but it does not stimulate FSH and hence will not maintain testicular health. (it's been tried many times in studies by the way...)
Armidex does dick for FSH and testicular function and I wouldn't use it period in your case as you'll simply supress your estrogen too low and that has MANY negative effects downstream of the process.
You haven't even mentioned HCG, which would be the one thing in the world that would actually maintain a healthy FSH profile in light of adding exogenous test....and you should know better than that.
Again...my question...why add the test? What is the purpose of it?
Here's a link to PubMed that will allow you to research Hormone Replacement Therapies and the like.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
WideAwake
02-23-04, 10:15 AM
By the way, from what I understand you need to shoot IGF intramuscular into the muscle group you wish to enhance.
In this case, your dick I would think.
I am interested in seeing how this pans out for you, but I think you should run the IGF solo the first time.
IGF can cause a lot of things to go screwy in your system if you don't know what to look for (i.e., hypoglycemia is a common report...)
I might Run the IGF-1 By its self for the first month. I am only going to take the Arimidex once or twice a week. It is the god of estrogen antagonists
I ma using the test for muscle benifits man.
Hints to get the most out of a Long R cycle!
1) Stack it with AS! Yes, there are a lot of people out there to say do it alone so you can evaluate how you respond to it by itself first. Well that's nice if you are strictly a research scientist but in reality all we really care about is adding lean mass. Stacking Long R with AS produces a synergistic effect. This is true about GH and is true about Long R.
1a) Wait until all your AS has kicked in before starting IGF!
2) Increase your protein grams into the mega dose range. This means 2.5x to 3.0x bodyweight. Muscle is protein! Long R seems to be much more effective under these conditions. There is a study that backs this up and plenty of anecdotal evidence.
3) Don't expect to gain weight! Long R recomps you. In all likelyhood you'll end up loosing weight. The scale is not a good judge of Long R. The mirror and a tape measure are much better qualified to evaluate the effects of Long R. If your lifts increase, calories haven't been cut, AS remains the same but your weight suddenly heads south it's the Holy Grail of bodybuilding. Gaining muscle and loosing fat at the same time!
4) Not everyone gets the sides. Not everyone gets all the sides. Some people get no sides. Sides include- crazy assed pumps, uncontrolable appetite, sleepyness, headaches, weird acne.
WideAwake
02-23-04, 10:27 AM
Like to hear it!
I'm really looking forward to seeing how this runs for you.
Again though, estrogen is your friend for growth and you do need it in regard to mDNA and protein synthesis. When you're running 750mg/test week or more it makes sense to keep it in check, but otherwise it will crash out your estrogen levels and that will put the brakes on any growth you wish to achieve.
Sounds like a plan though.
When do you start?
As soon as I get all the stuff in
Lok at al my anti- estrogen stuff im going to be fine
Not with the clomid and Ring of Power and the Arimidex, it will not let it happend, no way in hell am i going to make that mistake again brotha!!
Good to know you know what you're doing! I wish you the best of luck :)
Btw, Have you tried Tribex at all? Tribulus Terresteris.
Yea, my ring is better than those
quijjiboo
02-23-04, 01:31 PM
You've already posted somewhere that your natural test levels come in around 900ng/dl...that's an amazingly high level of natty test for ANYONE!
200mg/week will supress your natural test production in as little as two weeks.
200mg/week will NOT bring you levels even near 900ng/dl.
So you're basically going to shut yourself down again and not even have the benefit of increasing your testosterone levels higher than they already are in your natural state.
yea I agree, with your bad cycle you were doing what 750mg/week of test??
With 400mg/week along with HCG and anti-e's I think you should recover fine. I just don't think 200mg is worthwhile
OK we will see, I might try IGF-1LR3 for the fist month alone to see what it does then after I get off, go straint to the test for 4 weeks alone, then 4 weeks with the IGF-1LR3 what you think?
LeeJunFan
02-23-04, 01:48 PM
just curious, how does the Ring of Power affect your testosterone levels?
WideAwake
02-23-04, 01:52 PM
OK we will see, I might try IGF-1LR3 for the fist month alone to see what it does then after I get off, go straint to the test for 4 weeks alone, then 4 weeks with the IGF-1LR3 what you think?
Test Depo (which is either test ethanate or test cypanate) takes at least 4-5 weeks to build up to super-physiological levels in your system. (it's a LONG ester test).
So you're not even going to see anything running it for only four weeks, and you'll be shut down to boot.
Run it 8-10 weeks or don't run it at all.
Get yourself some hcg and run that 500iu on Mon and Thur as well throughout the whole cycle.
Should I just do the IGF-1 First? I was going to run the test for 8 weeks, ony the IGF-1 on for 4 and off
xtremegamer
02-23-04, 02:26 PM
I wish you the best of luck Supra. I'm guessing 9x7 at a minimum will soon be arriving. Supra is going to be like his car. For thos of you that don't know, Supra's can have 1000+ BHP on a stock bottom end.
turkzilla
02-23-04, 03:05 PM
be careful dude
ItsElectric
02-23-04, 03:13 PM
Hmmm, very intereting.
-ItsElectric
WideAwake
02-23-04, 03:18 PM
Should I just do the IGF-1 First? I was going to run the test for 8 weeks, ony the IGF-1 on for 4 and off
Yes.
I would run the IGF for 4 weeks. Take 4 weeks off to give yourself a break, than start the 8 week test cycle.
I would than start the IGF up again about 2-3 weeks into the test cycle.
My 2 cents.
WideAwake
02-23-04, 03:20 PM
Hey man, you didn't order IGF from the place associated with muscle chem did you?
I've heard some very bad things in the last couple of days...
Nope, no way, that place is going down
I will do IGF-1 for the first month
Test the second month
Igf-1 and test the third month
REDZULU2003
02-23-04, 03:48 PM
This IGF-1 should go well I hope, goodluck.
WideAwake
02-23-04, 04:19 PM
I will do IGF-1 for the first month
Test the second month
Igf-1 and test the third month
Word.
I'm really looking forward to seeing how this goes for you.
philadelph
02-23-04, 06:21 PM
[QUOTE=Supra]Do not do this if you dont know what you are doing and have no knowlege on this stuff, let me try it first and lets see my results.
I just ordered IGF-1LR3, Testosterone Depot, and Clomid
I am going to take the IGF-1 5 on 2 off 50mg's a day 4 weeks on and 4 weeks off
QUOTE]
Don't you mean micrograms for the IGF-1?
BamBam22
02-23-04, 06:32 PM
If you follow proper post cycle therapy (PCT) you shouldn't have too much of a problem with the after cycle crash. Using clomid after the cycle for three weeks or so along with the HCG should be ok...I'd look up some more info on your cycle before you jump into it, especially in the PCT side of a cycle. Also, while winny wouldn't be bad to stack with the test, stay away from the deca and tren if you wanna do PE, cause they are reknown for causing "deca-dick"...meaning no wood no matter how much Cialis you throw in.
Supra,
I know your serious about doing this so.
But why don't you use something like Primobolan depot or Deca?? It would have a profoundly less effect on your own testosterone levels.
philadelph
02-23-04, 06:57 PM
Supra,
I know your serious about doing this so.
But why don't you use something like Primobolan depot or Deca?? It would have a profoundly less effect on your own testosterone levels.
Not true at all. Both of those will still surpress his natural testosterone. Deca will shut you down arguably longer than any compound ! While these are shutting him down, he will feel like shit and have no sex drive because he needs testosterone to feel like a man ! This is why you always base a cycle around testosterone.
Not true at all. Both of those will still surpress his natural testosterone. Deca will shut you down arguably longer than any compound ! While these are shutting him down, he will feel like shit and have no sex drive because he needs testosterone to feel like a man ! This is why you always base a cycle around testosterone.
I know that these will shut down him down. But, Not as quickly as TEST. Also, Supra has stated that he did not react favorably to test. Yes, he mentioned taking it at higher levels then the 200mg he has mentioned here.
But, test is the quickest way to raisin nuts. We all know this. Also, you can take all the anti-aromatases that you want. It will still be suppressed and the AA's do get in the way of the test's results. Plus, when he stops no matter what he'll feel like shit and have no sex drive. That's a given. I didn't react well at all with test. But deca was great to me. I know that it gets a bad rap for being a libido killer. But I never had a problem with that at all. I used that with GH and had a phenomenal result from it. W/o the side effects that test gave me.
I read somewhere that arimidex will lower IGF levels.. and some other drug won't. It was somewhere on the bodybuilding.com forums. then again, you're taking igf, that should counteract it.
doublelongdaddy
02-23-04, 08:17 PM
How is the research end of this coming SUPRA? Have you found some good info online to study? I just got back into town and have not had the time to do as much reading on this as I would like. Post some of the info that you read or links so I can catch up.
DLD
quijjiboo
02-23-04, 08:31 PM
I read somewhere that arimidex will lower IGF levels.. and some other drug won't. It was somewhere on the bodybuilding.com forums. then again, you're taking igf, that should counteract it.
You probably read about Nolvadex lowering IGF-1, its pretty good at that. Possibly Clomid too since they are very similar compounds.
Arimidex is quite different from those 2, and I have never seen any studies about Arimidex lowering IGF-1, thats one of the reasons why I recommended that over Clomid on cycle.
Gardenier90
02-23-04, 08:47 PM
Very interesting.
philadelph
02-23-04, 09:36 PM
I know that these will shut down him down. But, Not as quickly as TEST. Also, Supra has stated that he did not react favorably to test. Yes, he mentioned taking it at higher levels then the 200mg he has mentioned here.
But, test is the quickest way to raisin nuts. We all know this. Also, you can take all the anti-aromatases that you want. It will still be suppressed and the AA's do get in the way of the test's results. Plus, when he stops no matter what he'll feel like shit and have no sex drive. That's a given. I didn't react well at all with test. But deca was great to me. I know that it gets a bad rap for being a libido killer. But I never had a problem with that at all. I used that with GH and had a phenomenal result from it. W/o the side effects that test gave me.
I agree with some of your points, however I would have to say Tren would shut you down quickest. Some have even suspected that a low dose booster of test will not shut you down. I am glad you had great results anddidn't have lack of sex drive on deca, you are a younger guy right?
I am not sure what this means:
"Also, you can take all the anti-aromatases that you want."
quijjiboo
02-23-04, 10:01 PM
For someone who gets supressed easily from gear ya Deca and Tren are out of the question. Deca is extremely long acting, not only because of the heavy decanoate ester, but the drug itself just doesn't want to go away. It is detectable in the body for 2 years, way longer than any other.
Some people have theorized that Deca was really popular a long time ago because they experienced less crash when they used it. They did not use HCG or anti-e's back then, so they usually crashed hard, but the long acting deca acted as a sort of natural taper.
And tren is just the devil's juice rofl
quijjiboo
02-23-04, 10:14 PM
My prediction is that Supra is going to see really good results with the IGF-1. It causes growth throughout the whole body, pretty much everything, and with a stimulus like PE the growth will be accelerated even more. And PE really is a stimulus for tissue growth, it doesn't just stretch, DLD's 9X6 flaccid doesn't just come from stretched tissue hehehe, that's growth.
It's like with muscular growth, with weight training you will gain x, with IGF-1 (or an anabolic steroid) you will gain y, but combining the two you will get much greater than x+y due to the synergy.
I agree with some of your points, however I would have to say Tren would shut you down quickest. Some have even suspected that a low dose booster of test will not shut you down. I am glad you had great results anddidn't have lack of sex drive on deca, you are a younger guy right?
I am not sure what this means:
"Also, you can take all the anti-aromatases that you want."
I was being a little sarcastic, what I was saying is that you can take anti-aromatases but it doesn't negate all the side effects from the test. Maybe with the gyno. I didn't see if Supra mentioned HCG at all. If he was gonna bodybuild, I agree Test by far is the base of all stacks. I just don't know for his reasons if its best. D-bol along with Tren I think would be the quickest to shutdown test production. Ofcourse finding real D-bol is a whole other story, now usually mixed with methyl-test I believe thats the deal with it. And actually I am 33, I did it last year, when I was getting a couple of guys ready for some shows.
I read somewhere that arimidex will lower IGF levels.. and some other drug won't. It was somewhere on the bodybuilding.com forums. then again, you're taking igf, that should counteract it.
Novadex lowers IGF not Arimidex
I know that these will shut down him down. But, Not as quickly as TEST. Also, Supra has stated that he did not react favorably to test. Yes, he mentioned taking it at higher levels then the 200mg he has mentioned here.
But, test is the quickest way to raisin nuts. We all know this. Also, you can take all the anti-aromatases that you want. It will still be suppressed and the AA's do get in the way of the test's results. Plus, when he stops no matter what he'll feel like shit and have no sex drive. That's a given. I didn't react well at all with test. But deca was great to me. I know that it gets a bad rap for being a libido killer. But I never had a problem with that at all. I used that with GH and had a phenomenal result from it. W/o the side effects that test gave me.
I am throwing out the testosterone and just going to Use the IGF for the first month, I want to see what this alone with 2 rings on, clomid and HCG and the Cialis does
My prediction is that Supra is going to see really good results with the IGF-1. It causes growth throughout the whole body, pretty much everything, and with a stimulus like PE the growth will be accelerated even more. And PE really is a stimulus for tissue growth, it doesn't just stretch, DLD's 9X6 flaccid doesn't just come from stretched tissue hehehe, that's growth.
It's like with muscular growth, with weight training you will gain x, with IGF-1 (or an anabolic steroid) you will gain y, but combining the two you will get much greater than x+y due to the synergy.
With my vigorous PE routine, IGF, Cialis, Clomid, HCG and arimidex I am going to get serious growth and the clomid and hcg and arimidex will make my balls absoluty huge
How is the research end of this coming SUPRA? Have you found some good info online to study? I just got back into town and have not had the time to do as much reading on this as I would like. Post some of the info that you read or links so I can catch up.
DLD
Hey bro, im starting the IGF-1LR3 this week as soon as I recive it
WideAwake
02-24-04, 10:57 AM
Arimidex has been clinically proven to reduce IGF-1 levels.
See below.
Everyone by now has heard of Arimidex/Liquidex(ie anastrozole) but there are a couple others with slightly better estrogen suppression values as well as slight differences in the way they affect the endocrine system.
The other two 3rd generation Anti-e's are letrozole(femara) and exemestane(aromasin). Letrozole and anastrozole are aromatase inhibitors while exemestane is considered an aromatase inactivator.
While all of these seem to exert an effect on our LH/FSH levels, some also have an effect on IGF-1 levels as well. According to some studies for example, anastrzole was shown to reduce IGF-1 levels by 18%(note 1), which is likely due to reduced estrogen. Another abstract shows that letrozole actually increased IGF-1 levels by an average of 24%(note 2).
Following are some detailed descriptions of the 3 products.
notes:
1. J Clin Endocrinol Metab 2000 Jul;85(7):2370-7
2. J Steroid Biochem Mol Biol 1997 Nov-Dec;63(4-6):261-7
It probably won't matter with the amount of exogenous IGF you'll be pumping (and yes it is in mcg amounts not mg amounts to whomever asked that...).
WideAwake
02-24-04, 10:58 AM
Letrozole.
DESCRIPTION
Femara (letrozole tablets) for oral administration contain 2.5 mg of letrozole, a nonsteroidal aromatase inhibitor (inhibitor of estrogen synthesis). It is chemically described as 4,4'-(1H-1,2,4 -Triazol-1-ylmethylene) dibenzonitrile.
Letrozole is a white to yellowish crystalline powder, practically odorless, freely soluble in dichloromethane, slightly soluble in ethanol, and practically insoluble in water. It has a molecular weight of 285.31, empirical formula C17H11N5 and a melting range of 184o C-185o C.
Femara (letrozole tablets) is available as 2.5 mg tablets for oral administration.
Inactive Ingredients.
Colloidal silicon dioxide, ferric oxide, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, maize starch, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, talc, and titanium dioxide.
CLINICAL PHARMACOLOGY
Mechanism of Action
The growth of some cancers of the breast are stimulated or maintained by estrogens. Treatment of breast cancer thought to be hormonally responsive (i.e., estrogen and/or progesterone receptor positive or receptor unknown) has included a variety of efforts to decrease estrogen levels (ovariectomy, adrenalectomy, hypophysectomy) or inhibit estrogen effects (antiestrogens and progestational agents). These interventions lead to decreased tumor mass or delayed progression of tumor growth in some women.
In postmenopausal women, estrogens are mainly derived from the action of the aromatase enzyme, which converts adrenal androgens (primarily androstenedione and testosterone) to estrone and estradiol. The suppression of estrogen biosynthesis in peripheral tissues and in the cancer tissue itself can therefore be achieved by specifically inhibiting the aromatase enzyme.
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumorbearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.
Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues. Treatment of women with letrozole significantly lowers serum estrone, estradiol and estrone sulfate and has not been shown to significantly affect adrenal corticosteroid synthesis, aldosterone synthesis, or synthesis of thyroid hormones.
Pharmacokinetics
Letrozole is rapidly and completely absorbed from the gastrointestinal tract and absorption is not affected by food. It is metabolized slowly to an inactive metabolite whose glucuronide conjugate is excreted renally, representing the major clearance pathway. About 90% of radiolabeled letrozole is recovered in urine. Letrozole’s terminal elimination half-life is about 2 days and steady-state plasma concentration after daily 2.5mg dosing is reached in 2-6 weeks. Plasma concentrations at steady-state are 1.5 to 2 times higher than predicted from the concentrations measured after a single dose, indicating a slight nonlinearity in the pharmacokinetics of letrozole upon daily administration of 2.5mg. These steady-state levels are maintained over extended periods, however, and continuous accumulation of letrozole does not occur. Letrozole is weakly protein bound and has a large volume of distribution (approximately 1.9 L/kg).
Metabolism and Excretion
Metabolism to a pharmacologically-inactive carbinol metabolite (4, 4'-methanol-bisbenzonitrile) and renal excretion of the glucuronide conjugate of this metabolite is the major pathway of letrozole clearance. Of the radiolabel recovered in urine, at least 75% was the glucuronide of the carbinol metabolite, about 9% was two unidentified metabolites, and 6% was unchanged letrozole.
In human microsomes with specific CYP isozyme activity, CYP 3A4 metabolized letrozole to the carbinol metabolite while CYP 2A6 formed both this metabolite and its ketone analog. In human liver microsomes, letrozole strongly inhibited CYP 2A6 and moderately inhibited CYP 2C19.
Special Populations
Pediatric, Geriatric and Race: In the study populations (adults ranging in age from 35 to >80 years), no change in pharmacokinetic parameters was observed with increasing age. Differences in letrozole pharmacokinetics between adult and pediatric populations have not been studied. Differences in letrozole pharmacokinetics due to race have not been studied.
Renal Insufficiency: In a study of volunteers with varying renal function (24-hour creatinine clearance: 9-116 mL/min), no effect of renal function on the pharmacokinetics of single doses of 2.5mg of Femara (letrozole tablets) was found. In addition, in a study of 347 patients with advanced breast cancer, about half of whom received 2.5mg Femara and half 0.5mg Femara, renal impairment (calculated creatinine clearance: 20-50 mL/min) did not affect steady-state plasma letrozole concentration.
Hepatic Insufficiency: In a study of subjects with varying degrees of non-metastatic hepatic dysfunction (e.g., cirrhosis, Child-Pugh classification A and B), the mean AUC values of the volunteers with moderate hepatic impairment were 37% higher than in normal subjects, but still within the range seen in subjects without impaired function. Patients with severe hepatic impairment (Child-Pugh classification C) have not been studied (see DOSAGE AND ADMINISTRATION, Hepatic Impairment).
Drug/Drug Interactions
A pharmacokinetic interaction study with cimetidine showed no clinically significant effect on letrozole pharmacokinetics. An interaction study with warfarin showed no clinically significant effect of letrozole on warfarin pharmacokinetics.
There is no clinical experience to date on the use of Femara in combination with other anti-cancer agents.
Pharmacodynamics
In postmenopausal patients with advanced breast cancer, daily doses of 0.1 mg to 5 mg Femara suppress plasma concentrations of estradiol, estrone, and estrone sulfate by 75%-95% from baseline with maximal suppression achieved within two-three days. Suppression is dose-related, with doses of 0.5 mg and higher giving many values of estrone and estrone sulfate that were below the limit of detection in the assays. Estrogen suppression was maintained throughout treatment in all patients treated at 0.5 mg or higher.
Letrozole is highly specific in inhibiting aromatase activity. There is no impairment of adrenal steroidogenesis. No clinically-relevant changes were found in the plasma concentrations of cortisol, aldosterone, 11-deoxycortisol, 17-hydroxy-progesterone, ACTH or in plasma renin activity among post-menopausal patients treated with a daily dose of Femara 0.1 mg to 5 mg. The ACTH stimulation test performed after 6 and 12 weeks of treatment with daily doses of 0.1, 0.25, 0.5, 1, 2.5, and 5 mg did not indicate any attenuation of aldosterone or cortisol production. Glucocorticoid or mineralocorticoid supplementation is, therefore, not necessary.
No changes were noted in plasma concentrations of androgens (androstenedione and testosterone) among healthy postmenopausal women after 0.1, 0.5, and 2.5 mg single doses of Femara or in plasma concentrations of androstenedione among postmenopausal patients treated with daily doses of 0. 1 mg to 5 mg. This indicates that the blockade of estrogen biosynthesis does not lead to accumulation of androgenic precursors. Plasma levels of LH and FSH were not affected by letrozole in patients, nor was thyroid function as evaluated by TSH levels, T3 uptake, and T4 levels.
WideAwake
02-24-04, 11:01 AM
Subjectively -
I've run dex and I've run fem.
They both work like a champ, but Femara is much better at holding off water and lean gains.
That being said, I think adding either to 200mg or 400mg of test a week is a BAD idea as it will have major negatives on both blood, lipid and cholesteral levels.
You need estrogen to grow guys...it's not a bad thing. It's only bad when you have a ratio that far exceed the normal est/test parameters.
I wouldn't use either if I was you Sup.
My 2 cents.
Good work with the research WideAwake!!!!
That's one of the great points about the forums..........people with the opportunity to post some important information that others while interested may not be able to find.
quijjiboo
02-24-04, 11:08 AM
Good read WideAwake..
That's why I don't take anti-e's at all, they all have their side effects, it's not like you don't have enough sides to worry about when you're on a cycle.. I try to keep it as clean as possible
philadelph
02-24-04, 11:19 AM
It does seem like too many people start going heavy on the anti-e's/serms without even seeing problems arise first. Most people will not have serious sides that merit their heavy use.
WideAwake
02-24-04, 11:20 AM
Good read WideAwake..
That's why I don't take anti-e's at all, they all have their side effects, it's not like you don't have enough sides to worry about when you're on a cycle.. I try to keep it as clean as possible
Word bro, you and I are on the same page on that one.
No need for any anti-e's unless - A) you start having sides arise (gyno) or B) you're running a gram a week of test and others (and I've NEVER done anything like that...).
The olnly time I've ever run any is when I need to cut up and dry out for a beach trip or some crap like that. In that case I have used some Femara for a 2 week stint, and although it's great at 'drying' you out and giving you that ripped up look (if you're already below 8-9% body fat, if not...don't even think about it...) it does play hell with a ton of your values (and yes I do get blood work done all the time so I do know what does and does not effect my levels...)
WideAwake
02-24-04, 11:21 AM
It does seem like too many people start going heavy on the anti-e's/serms without even seeing problems arise first. Most people will not have serious sides that merit their heavy use.
To clarify, for post-cycle therapy, I'm all about a clomid/nolva combo...this has worked best for me personally.
(with the use of HCG at 500iu mon/thur through the entire cycle...)
Well I am canning the arimidex and the Test cypinate
I am going to use the IGF and Clomid and some HCG here and there to blow my balls up ROFLMAO!!!
Thanks wide awake so much and the rest of you guys for looking out for me, I would not be here if it was not for yall.
That test I know would fuck me up again and the Arimdex would go against the IGF
WideAwake
02-24-04, 12:02 PM
Well I am canning the arimidex and the Test cypinate
I am going to use the IGF and Clomid and some HCG here and there to blow my balls up ROFLMAO!!!
Thanks wide awake so much and the rest of you guys for looking out for me, I would not be here if it was not for yall.
That test I know would fuck me up again and the Arimdex would go against the IGF
DUDE!!!!
Now you're talking!!!
I'm so glad to see you ditch the test and dex...I really think you'll get so much more out of the IGF, and be able to actually have an accurate evaluation of how it is working for you without any other factors.
Use HCG only at 500iu/day, with at least 48 hours between injects or you will hurt some of the leydig cells in your testes. (I like Mon/Thur as I've posted above.)
And than just careful with the clomid, if you start seeing 'trails' or 'streaks' or have any probs with your vision, stop using clomid at once. It can have some bad sides on vision in some people (me if I go over 50mg/day...).
WideAwake
02-24-04, 12:11 PM
Ok...now that we've got THAT out of the way....
I do think androgens (if you could localize them to the penis only...) would have a VERY positive roll in this process. Combined with the IGF they would almost certainly provide more growth than without.
Of course the problem has always been, how do you get androgens into your dick and not anywhere else in your body?
Some of the folks on here have talked about using the transdermal 4ad and other stuff and rubbing that in to the penis. I personally don't think that will work at all, as almost all the carriers are designed to deliver the actives (adrogens such as 4ad) systemically (throughout your entire circulatory system).
So how can you get androgens delivered locally to the penis tissue, with no systemic uptake into the circulatory system?
Well...there just so happens to be a product on the market (that I've used for localized growth on my arms and chest) that does deliver androgens to localized tissue, without any systemic uptake.
Sounds nice huh?
It's produced by a company called "Avant Labs" and it's called "Gel #3".
You can look it up on thier website...
http://www.avantlabs.com/
Now, if one was to take this Gel #3, and add...oh I don't know...say 3grams of 3alpha (DHT precursor) and 3grams of 5AA (other side of the 3alpha fence...but basically another DHT precursor), or perhaps just 6grams of 3alpha...well than kids I think you have a recipie that not only delivers the best DHT precursor around, but does so only to the tissue it's applied to.
Just a thought...I wanted to throw it out there as many of the posts in regard to the 4ad stuff were way off base.
Peace,
WA
quijjiboo
02-24-04, 12:38 PM
I don't see anything special about that transdermal. The ingredients are:
Isopropyl alcohol, benzyl alcohol, octyl salicylate, triglyceride complex, water, d-limonene, carbomer
The only ingredient that I haven't seen in other transdermals is octyl salicylate, is that the magic bullet?? The oils (or the 'triglyceride complex') just act as penetration enhancers, making the skin absorb a higher amount of the hormone in the skin. D-limonene and carbomer are to give it better texture IINM.
What's its missing is dsmo, which is a very effective carrier. I think there's better transdermals out there than that one, check my trandermal test experiment thread in the health forum for a good formula.
WideAwake
02-24-04, 01:02 PM
I don't see anything special about that transdermal. The ingredients are:
Isopropyl alcohol, benzyl alcohol, octyl salicylate, triglyceride complex, water, d-limonene, carbomer
The only ingredient that I haven't seen in other transdermals is octyl salicylate, is that the magic bullet?? The oils (or the 'triglyceride complex') just act as penetration enhancers, making the skin absorb a higher amount of the hormone in the skin. D-limonene and carbomer are to give it better texture IINM.
What's its missing is dsmo, which is a very effective carrier. I think there's better transdermals out there than that one, check my trandermal test experiment thread in the health forum for a good formula.
DMSO is a great carrier for delivering actives SYSTEMICALLY!!!!!
You don't want to do that or you run into the same probs that we have discussed above.
From experience I've run the gel #3 with 1test on my delts and pecs for 4 weeks. Both my delts and pecs gained size/strength to a significant and noticable degree ( I know when something is working and when it's not )
Blood work:
Total test prior to 4 week cycle was 740ng/dl
Total test a week after the 4 week cycle was 750ng/dl
Bottom line is that I didn't have any decrease in natty test, and I saw great results.
There isn't another gel on the market that can do that. Period.
doublelongdaddy
02-24-04, 01:11 PM
WIDE, Thanks for the info. I am also very interested in case studies if you have any access to that.
DLD
quijjiboo
02-24-04, 01:32 PM
DMSO is a great carrier for delivering actives SYSTEMICALLY!!!!!
You don't want to do that or you run into the same probs that we have discussed above.
From experience I've run the gel #3 with 1test on my delts and pecs for 4 weeks. Both my delts and pecs gained size/strength to a significant and noticable degree ( I know when something is working and when it's not )
Blood work:
Total test prior to 4 week cycle was 740ng/dl
Total test a week after the 4 week cycle was 750ng/dl
Bottom line is that I didn't have any decrease in natty test, and I saw great results.
There isn't another gel on the market that can do that. Period.
Back in the day, the owner of Avant Labs, designer of that gel used to go on bodybuilding.com alot and answer questions about his shit, and he said himself that there is no local action.
Not only that, many people have tried to specialize a bodypart by applying 1test, 4ad, test, tren whatever with a similar transdermal and it don't work. The vast majority of people who use bodybuilding transdermals apply it to their upper body (arms chest delts), I think that community would realize it only worked locally if that was the case!
Could there be a chance that you were working your delts and pecs harder than the other groups, since you were specializing? I think so. That would account for your results.
Almost everybody experiences some sort of crash off of a transdermal hormone cycle, if it was only local and didn't supress testosterone, how is this possible?
Again, there's nothing special about that formula, theres alcohols as solvents, oils to condition the skin and encourage penetration, and there's D-lim and carbomer for a better consistency.
philadelph
02-24-04, 02:19 PM
Back in the day, the owner of Avant Labs, designer of that gel used to go on bodybuilding.com alot and answer questions about his shit, and he said himself that there is no local action.
Not only that, many people have tried to specialize a bodypart by applying 1test, 4ad, test, tren whatever with a similar transdermal and it don't work. The vast majority of people who use bodybuilding transdermals apply it to their upper body (arms chest delts), I think that community would realize it only worked locally if that was the case!
Could there be a chance that you were working your delts and pecs harder than the other groups, since you were specializing? I think so. That would account for your results.
Almost everybody experiences some sort of crash off of a transdermal hormone cycle, if it was only local and didn't supress testosterone, how is this possible?
Again, there's nothing special about that formula, theres alcohols as solvents, oils to condition the skin and encourage penetration, and there's D-lim and carbomer for a better consistency.
You really don't know what your talking about man. Go to the avant labs forum, you shall see. They are actually doing testing right now. As for the gel # 3, someone has made a 3-alpha and said it worked. With the PE I would guess it would work much better and you would see enhanced recovery.
WideAwake knows his shit.
WideAwake
02-24-04, 02:53 PM
You really don't know what your talking about man. Go to the avant labs forum, you shall see. They are actually doing testing right now. As for the gel # 3, someone has made a 3-alpha and said it worked. With the PE I would guess it would work much better and you would see enhanced recovery.
WideAwake knows his shit.
Word. I'm not in the mood to debate this any longer, I gave my advise and some logic to support the idea, what others do with the concept is thier own affair.
Black Star Labs actually bought the rights to the localized gel and now sell it on thier site as well, and you can even pick what prohormone you wish to have added. (though I would just do it myself with the direct avant product).
http://www.blackstarlabs.com/?cPath=19&products_id=92
erm1981
02-24-04, 02:55 PM
Yes im interested in seeing how this goes for you Supra
WideAwake
02-24-04, 03:05 PM
WIDE, Thanks for the info. I am also very interested in case studies if you have any access to that.
DLD
Here you go bro, some links to various threads on this topic
For the most part this 'product' has been referred to as "Sytenhance", which is the brand name of the Black Star Labs product.
The product started out as a beta type gel back a while ago on the Avant board, and a bunch of us used it with a large degree of success, now it's being offered to a much larger market via the Black Star Labs company (not directly related to Avant, but they work in partnership on a lot of products).
http://forum.bodybuilding.com/showthread.php?threadid=231174
http://forum.bodybuilding.com/showthread.php?threadid=227601
http://forum.bodybuilding.com/showthread.php?threadid=171674
http://forum.bodybuilding.com/showthread.php?threadid=183755
This one is VERY good...
http://forum.bodybuilding.com/showthread.php?threadid=170918
http://forum.bodybuilding.com/showthread.php?threadid=172632
There are many others...just do a search for "Sytenhance" on bodybuilding.com.
There's also a post over on the Avant board were a bunch of folks actually thought out how to apply it to PE....with some questions still remaining...
I'm jammed up right now or I'd post a link, but just do a search on the avant message board for "hung" and see what comes up...
WideAwake
02-24-04, 03:20 PM
Here's the 'hung' link on the avant board
http://forum.avantlabs.com/?act=ST&f=1&t=2219&hl=&
quijjiboo
02-24-04, 04:17 PM
Wasn't aware there was such a thing out there, been out of the bodybuilding transdermal game for a long time..
Thing that puzzles me though is that's almost the exact same ingredients I and others have been using for a while ?:(
and Philadelph, if you dont have shit to say other than "you dont know what youre talking about" nothing productive then shut the fuck up
philadelph
02-24-04, 07:46 PM
Wasn't aware there was such a thing out there, been out of the bodybuilding transdermal game for a long time..
Thing that puzzles me though is that's almost the exact same ingredients I and others have been using for a while ?:(
and Philadelph, if you dont have shit to say other than "you dont know what youre talking about" nothing productive then shut the fuck up
I have read the threads and researched gel # 3. You are stating that this could not possibly work, and is the same as a systemic gel carrier. Therefore I assume you have not done your research lately. No need to get pissy.
I cannot wait!!! WERE IS MY IGF@@@@@!!!1
randolf
02-25-04, 02:21 AM
Here's the 'hung' link on the avant board
http://forum.avantlabs.com/?act=ST&f=1&t=2219&hl=&
hahhaaa one of the guys on that hung link had a good comeback.
'Its not the size of the organ, its the size of the church it plays in.'
I am the the the fucking lab rat for the fucking forum, damn you guys for making me try everything first!!! "He made me do it" !!!!!
WideAwake
02-25-04, 07:58 AM
Thing that puzzles me though is that's almost the exact same ingredients I and others have been using for a while ?:(
It's a safe bet to assume their may be a few substrates in there that may have accidentally been left off the labels....
Supra ... just thought I'd let you know that I ordered some IGF-1, received it on monday, started taking monday afternoon. First dose I ever took, I popped a woody right after taking it (oral spray). Mine only has 2000ng (yes, that's an n for nano) "of IGF-1, also IGF-2 and other growth factors". All six doses I've taken I've gotten the same effect and last night I woke up twice throughout the night and again when I woke up. All 3 times with raging hard ons.
So I think it's working pretty well, but haven't gotten to a stage where I can take any of this as real results. Could have just been a night of great dreams last night and I'm testing like a placebo. :) Good luck bro.
The IGF I am going to use is recombat DNA, i inject it, this is not a supplement you buy at a store
What is yours?
Girthius
02-25-04, 02:46 PM
I found these IGF2 pills for penis enlargement. Are these worth anything or just bullshit?www.americanlifestyle.com (http://)
Once you get to the home page, type in IGF2 in the search box, it should come up then. Once IGF2-700mg comes up, click on that, and it will give you the product discription!
Girthius
The only way to get real IGF is to inject the recombat DNA
quijjiboo
02-25-04, 03:07 PM
It's a safe bet to assume their may be a few substrates in there that may have accidentally been left off the labels....
That's what I would do too, but is that legal? Though Avant Labs is not the most law-conscious company around :P
quijjiboo
02-25-04, 03:08 PM
The only way to get real IGF is to inject the recombat DNA
Yep, IGF-1 would be destroyed in the gut
The IGF I am going to use is recombat DNA, i inject it, this is not a supplement you buy at a store
What is yours?
Just a spray you hold under your tongue.
The thing is that is not real IGF, that is just a supplemrnt, mine is made in a lab by bio chemists and doctors and stuff, the real deal.
9cyclops9
02-29-04, 02:02 AM
Supra when I see you you'd better not have grown an udder and start saying "MOO." I'll run away, I swear.
ROFLMAO, See i tell people to shoot cow hormones, but I dont take them!!! I take IGF-1LR3, the god of all growth factors
9cyclops9
02-29-04, 02:11 AM
Yeah you just don't want us to know you're secretly dumping the cow juice down your pee hole. You sick freak. Take those metal things off of your balls.
lol
I am a sicko!!! I know I know!! Whaaa, leave me alonE!!!! BLAHAHHAHAHHAHA
Im a sicko with huge bull balls!@!!!
9cyclops9
02-29-04, 02:15 AM
lol
I get a lot of haters casue my balls are bigger than anyone else's!! BLAHHAHAHAHHA
What you got?
9cyclops9
02-29-04, 02:18 AM
Oh yeah? Well you're GREEK!
Hungarians RULE! Go eat your Gyros and your falafel.
Girthius
02-29-04, 02:25 AM
Supra, since you live in Texas, perhaps you should adapt that old Bob Wills tune called " Big Balls in Cowtown" , I have! Also, where do you get this IGF-1LR3?
Girthius
Oh yeah? Well you're GREEK!
Hungarians RULE! Go eat your Gyros and your falafel.
BLAHAHAHAH See here come the haters!!! I got big balls!!!
Supra, since you live in Texas, perhaps you should adapt that old Bob Wills tune called " Big Balls in Cowtown" , I have! Also, where do you get this IGF-1LR3?
Girthius
I get it from a freind, pm me if you want to know more about it, I can get you some
philadelph
02-29-04, 01:17 PM
By the way supra, what dosage are you running the IGF? You said 50 mg on your first post, but I don't think you meant that.
Yea I did, you think, is that bad, thats what my Steriods 101 Book says and everything else. I was going to try 30mcg's but I think 50 might be better
philadelph
02-29-04, 01:46 PM
No I was actually talking about the mg., but you know its only mcg. I am really looking forward to your test. I am sure you will keep a detailed log.
swedeguy
02-29-04, 03:52 PM
Could someone help me out a bit? I have never tried test or anything like that so basically I don't understand much what you're talking about. However I really need to get bigger balls and a much bigger dick aswell as some serious muscle growth.
What exactly is HCG and IGF-1LR3? Are there any possible side effect? Is it even legal?
forgiven
02-29-04, 07:06 PM
Could someone help me out a bit? I have never tried test or anything like that so basically I don't understand much what you're talking about. However I really need to get bigger balls and a much bigger dick aswell as some serious muscle growth.
What exactly is HCG and IGF-1LR3? Are there any possible side effect? Is it even legal? Hey I would Suggest you check out WWW.INTENSE-TRAINING.com For some infoon steroids also go buy some books. Really do your research before you start.
I second that. If you dont know what your doing, Leave this stuff alone. The side effects are many and they are all nasty as hell.
If you plan on doing anykind of steriods or hormone therapies, I suggest you become a regular surfer at a good bodybuilding site and do at least 1-2 years good research on it.
I still dont think im ready for IGF or HGH and I have been looking at the subject for a long long time.
It is important to remember that by taking IGF or HGH, that it is not only your penis that will grow, your Hands, Feet, Jaw and Forehead will grow with it. This can cause some rather nasty looking caveman features. Not nice,
Check out www.hghnews.us for some more info
swedeguy
03-01-04, 10:22 AM
Hm, my jaw and forehead are "caveman-ish" enough as it is. :D
I just did my first shot of 50mg's. And 25mg's of Cialis. Hell YA!!
9cyclops9
03-01-04, 05:26 PM
Is it 10 inches yet?
rofl
philadelph
03-01-04, 08:35 PM
I second that. If you dont know what your doing, Leave this stuff alone. The side effects are many and they are all nasty as hell.
If you plan on doing anykind of steriods or hormone therapies, I suggest you become a regular surfer at a good bodybuilding site and do at least 1-2 years good research on it.
I still dont think im ready for IGF or HGH and I have been looking at the subject for a long long time.
It is important to remember that by taking IGF or HGH, that it is not only your penis that will grow, your Hands, Feet, Jaw and Forehead will grow with it. This can cause some rather nasty looking caveman features. Not nice,
Check out www.hghnews.us for some more info
I am far from an expert on this, but I thought that if your growth plates were closed your bones wouldn't grow?
I am at every bodybuilding site there is
philadelph. It is true that you wont grow taller if your long bones have fused, But there are areas that can will still be effected and try to grow like the ones I mentioned.
By the way. Good luck with this Supra. Im looking forward to seeing how this all goes
swedeguy
03-03-04, 03:53 PM
Does anyone have a link to a site with info specifically about IGF-1LR3 ?
I read a little bit on that hghnews.us and found this:
"HGH critics "fear" that people taking growth hormone who aren't closely monitored may take too large of an amount. This could put them at risk of a condition called acromegaly.
Indicators of acromegaly include a protruding brow or lower jaw and enlarged hands or feet. Doctors who support growth hormone treatment for aging say they don't prescribe doses high enough to approach the levels found in acromegaly."
Is there another site like that but for IGF?
I cant belive my parents dont send me to a shink or something after all this shit man, I made my dad watch when I shot it in my stomach!
I cant belive my parents dont send me to a shink or something after all this shit man, I made my dad watch when I shot it in my stomach!
Just don't bring your new girlfriend in on all this too soon, or too much at all. It may scare her off.
Your damn right it will!!
I you want to know how to get IGF-1LR3, Private Message me
swedeguy
03-04-04, 03:37 PM
I you want to know how to get IGF-1LR3, Private Message me
Supra, give us some more info about it dammit! *jealous*
:P
I cant man, ok look do reasearch on HGH and IGF on the net, tell me if you want some
Dude, my dick already looks bigger, its rock hard all day and I am barley PEing!!
Updates
Cialis Fucking Rules!!!! You want hard on anytime you want with out worring about Viagra, you got it, plus it works better, for me anyway
IGF-1LR3
I feel full of life, my penis looks thicker and I am loosing body fat like a mo fo. I can actually feel it in my body, when I work out, I feel my muscle Fibers and everything it is amazing. I cannot get mad, I feel happy all day and I got a smile on my face no matter what!! I feel a euphoric state around my whole body ans look on like. I have been suing it for 4 dayd now and feel amazing
your keeping your carbs up right???
AncientChina
03-04-04, 05:05 PM
Now I see....Supra no wonder you have had many more "BLAHAHA" posts....you must be on cloud9 bro. :cool:
Now I see....Supra no wonder you have had many more "BLAHAHA" posts....you must be on cloud9 bro. :cool:
Naw, mow Supra's gonna be giving "MooMooMoo" posts!!!!
AncientChina
03-04-04, 09:30 PM
Naw, mow Supra's gonna be giving "MooMooMoo" posts!!!!
Hehehe, I can't wait to squeeze his big milk titties MMMMMMMMMMM. Hey Supra hurry up man I need to fill up my bowl of Fruit Loops with some of your titty milk. :P
Dude, I am on Cloud 9 man, I am in a state of euphoria!!! ALL day!! ROFLMAO!!! TIs rocks!!
Dude, I am on Cloud 9 man, I am in a state of euphoria!!! ALL day!! ROFLMAO!!! TIs rocks!!
Be sure to read this message I found talking about using too much of the stuff for too long.
http://www.beyondmass.com/forums/showthread.php?threadid=6355
Hey thanks man, I am a member there, that is my best site fro IGF info!! Iread that a lot!! 30 days tops I am going to take it, then a month on then a month off!!! Hell yA!!
Hey thanks man, I am a member there, that is my best site fro IGF info!! Iread that a lot!! 30 days tops I am going to take it, then a month on then a month off!!! Hell yA!!
I wouldn't do it every other month even, since the compound is so new. But I suppose I'm more cautious than many. :)
I am a crazy fucking marine man, you know that!
Well first week down, as from my posts you can see I have had a great week!!!!
I am going for the next 21 days strait on this stuff, no more 5 on 2 off, I need results
1. Discoloration gone
2. Bigger penis
3. Bigger head
4. Les body fat
5. Bigg Balls
6. More Girth
7. .5 in length
8. Ance Cleared up
9. Hair regrown on head
10. Bigger Muscles
My special thanks and gratitude goes to Sliced Beef on all of this, I would nto be doing any of this if it was not for him, he is the one that has helped me with all of this, no only is he one of the coolest more informed guys here but he is my personal freind, thanks man, you are the best.
1. Discoloration gone
2. Bigger penis
3. Bigger head
4. Les body fat
5. Bigg Balls
6. More Girth
7. .5 in length
8. Ance Cleared up
9. Hair regrown on head
10. Bigger Muscles
Did you get all this from this stuff?
Those are what I am expecting from IGF, cials and the Ring of Power all together
ElCapitan
03-08-04, 10:06 AM
Hey Supra you are one crazy goddamn marine man. Well all I say is good luck. I have a question for you. Do you think there is a connection between PE and hairloss, because I seem to start losing hair more now that I do PE. Maybe PE is increasing testosteron which causes baldness. What do you think?
Lappner
I lost some hair from the Roids that I did, not PE
ElCapitan
03-08-04, 10:24 AM
Supra have you done anything to try to restore the hair growth. Did it work. Is there any good stuff that actually works?
Lappner
IGF my friend, HGH is supposed to re grow hair, and IGF is 10 stonger so, we will see!!
Well my new avatar is all about Genetics baby!!! Alterning my penis Genes!!! Making it bigger.
Second week second day of IGF Feeling great, penis is viasble larger all the time, and flaccid is full and pumped as well, not soft at all. Sex drive is up, metal attitude is up 10000% and my calves are getting huge
Body Fat Visable Down
Appitite Up
Strength Up
Balls Bigger
Vasular as hell
Erections Stronger than ever
And is the erect size bigger?
Just did my first shot of IGF-1 in the penis, I did 10mcg's on my penis and 30 in my stomach
swedeguy
03-11-04, 12:02 PM
Supra: Have you noticed any side effects?
Not yet, I just did it an hour ago
doublelongdaddy
03-11-04, 01:29 PM
I have not measures yet
Can't wait till you do
Can't wait till you do
Me too :gluedtosc
My prediction is that Supra is going to see really good results with the IGF-1. It causes growth throughout the whole body, pretty much everything, and with a stimulus like PE the growth will be accelerated even more. .
If it does cause growth throughout the body (I assume you mean muscle growth), then will it also enlarge the heart? Anyone know? That's probably not something anyone would want.
bgrand (student nurse)
fallen_one23
03-11-04, 01:42 PM
hmm there was some drug that makes EVERY thing bigger (from muscle to organs) is this similair to that, I don't think its dangerous, just want to know some more stuff about IGF before i start taking it
Oh yeah? Well you're GREEK!
Hungarians RULE! Go eat your Gyros and your falafel.
Watch it, hunky! ;-) :argument:
Greeks are cool, Russians are even better! :mixedup:
Ok, just kidding. Time for a brewski already :cheers:
hmm there was some drug that makes EVERY thing bigger (from muscle to organs) is this similair to that, I don't think its dangerous, just want to know some more stuff about IGF before i start taking it
I hear ya. I'm going to wait a few months and see what happens to Mr. Supra. He's got more/bigger balls than I do to begin with ;-) In the
mean time, I'm getting tips from DLD to get more growth the old fashioned way.
Bgrand
NeedMoreSize
03-12-04, 10:59 PM
If it does cause growth throughout the body (I assume you mean muscle growth), then will it also enlarge the heart? Anyone know? That's probably not something anyone would want.
bgrand (student nurse)
Over time with a high enough dose , IGF will enlarge hands, feet , skull , and all muscles including the heart but if you use IGF in moderation you can get the benefits of the penis enlargement with very little risk to your health.
PaloMalo
03-14-04, 10:08 AM
I am just a crazy fucker
I can tell...good luck :)
Supra and anyone else interested in this new area. I found this link. its a very good read. It also mentions something very interesting regarding myostatin. check it out
http://anabolicreview.com/vbulletin/showthread.php?t=15971
erm1981
03-16-04, 05:29 PM
Thats a real good read.....so if you take IGF-1LR3 by itself will it give some good muscles building results? They are also talking about growing new muscle fibers instead of the muscles just actually getting bigger which is really interesting. Did you read the part about the guy saying he might have changed his DNA for using te IGF-1LR3 for a few years. If this makes your penis bigger from direct injection it will be very interesting. If penis tissue was a lot like actual muscle tissue that would be great lol. Our dicks would get massive just from steroid use and jacking off. lol
Hell ya!! Were you been man? I have not seen ya on aim?
magnumforce
03-17-04, 10:05 AM
Supra,
Seems that this guy is doing some research in the same field. You should contact him!
http://www.urology.medsch.ucla.edu/cadavid.html
His name is cadavid, not cadaver, ok.
Thanks man, I cannot find a email though, any help?
Thanks man, I cannot find a email though, any help?
Here's the general contact info for the whole urology dept.:
From off campus:
UCLA Medical Center
Department of Urology
Box 951738
Los Angeles, CA 90095-1738
From on campus:
Department of Urology
66-138 CHS
Mail Code: 173818
by phone: (310)206-2355
by fax: (310)206-5343
by email: kbarrett@mednet.ucla.edu
There's a staff member directory (http://www.urology.medsch.ucla.edu/staff-list.html), but his name isn't on it.
Should I email them and tell them what i am doing you think?
Should I email them and tell them what i am doing you think? I have no idea of the legal status of these drugs (i.e. if they're controled substances). I'd try and get a hold of him if I were you, but if the drugs aren't exactly street legal, I'd speak cautiously but still try to get him to understand what you're doing. Hope that made sense.
Oh, and I wouldn't say anything to that email address beyond asking for the doctor's contact info and stating you think you might be a candidate for his research. That address isn't his personal one. It probably goes to some receptionist/secretary.
magnumforce
03-17-04, 10:54 AM
Supra, tell them to send you cadaver's personal email.
ok I did it, let see the response
ok I did it, let see the response
Good luck. Keep us updated.
No Problem, I wil glady give my self up for a research purposes
magnumforce
03-17-04, 12:38 PM
Supra, you're into serious BB, you should get myostatin antibodys!
Supra, you're into serious BB, you should get myostatin antibodys!
Supra, just im'd you his email address. He's an adjunct professor
at UCLA (as opposed to tenured/permanent).
Supra, you're into serious BB, you should get myostatin antibodys!
Tell me were and I will, I will shoot anything into my body, if it works
erm1981
03-17-04, 08:50 PM
yeah i would like those myostatin antibodies....i suppose you mean the blockers right?
magnumforce
03-18-04, 04:51 AM
I'm talking about antibodies! They bind to myostatin and therefore blocks it. It has resulted in incredible muscle mass gain on animal. It's still under research. It has been said human can laready get treatment in Csech Republic. It mainly works on skelletal muscles. Myostatin genes probably don't express in penile tissues, but who knows. If they do express, it might explain why some gain and others don't.
Antibodies can be purchased already.
http://www.biodesign.com/catalog2.asp?specificity=pro-Myostatin+(a.a.+79-92)&product=pro-Myostatin+(a.a.+79-92)
http://www.biodesign.com/bioSpecs/K24340R.doc
My bet is that BBers with use them very soon.
myostatin antibodies + igf1-r3 + steroids + insulin = 300 pounds at 5% fat!
Were can i get a myostatin inhibitor?
magnumforce
03-18-04, 10:38 AM
Supra, at biodesign.
gimmie a link! Wont this casue more hair loss?
erm1981
03-18-04, 10:36 PM
holy crap i had no idea you could by them now....very cool...and yeah of course you know bodybuilders will use them
Dude, do you get any of my pm's erm1881?
I need to start injecting more of this stuff
magnumforce
03-21-04, 12:14 PM
Myostatin and hair loss? No connection at all, man. Myostatin is presnt in squeletal muscles to prevent them from getting oversized.
Bigbadbison
03-24-04, 02:34 PM
Yellow,
I am new here and I am sorry if I missed it, but what is the theory behind injecting IGF2 into the penis? I assume it is supposed to make it bigger, but how?
Endocrinology has always been over me head, and Bison are tall!
Bbb
Bigbadbison
03-24-04, 03:30 PM
This dumb ungulate just re-read the first post.
This is very interesting and a little scary. Sounds like PubMed search time.
Bbb
Bigbadbison
03-26-04, 01:12 AM
ITS IGF-1LR3 not IGF2
Gosh and it is right there in the title. I better stick to manual work with the hoofs. I am scared of needles anyway.
Thanks
Bbb
magnumforce
03-26-04, 05:28 AM
Supra, you shouldn't take too much anti-estrogen, your penis needs them to grow!
Rather consider cosmetic surgery so you're done with the gyno issue. Even IGF-1 can produce gyno, you should know.
Supra, you shouldn't take too much anti-estrogen, your penis needs them to grow!
Rather consider cosmetic surgery so you're done with the gyno issue. Even IGF-1 can produce gyno, you should know.
I am not taking a lot, I am taking HCG and Clomid to make my nuts bigger. I have no gyno, I can not get it at all. No matter what, that is the least of my concerns, also les estrogen=more testosterone and a bigger cock.
magnumforce
03-26-04, 10:21 AM
no Supra, more DHT + little estrogen= bigger cock
Never take alpha 3 reductase inhibitors!
no Supra, more DHT + little estrogen= bigger cock
Never take alpha 3 reductase inhibitors!
What about IGF-1LR3 and DHT and Cialis?
gorillaunit
03-29-04, 11:26 AM
good thread. keep updating us supra
so what ever happened to this?
oops - my bad. shoulda realised this is what everyone is talking about in the other thread :P oh well, at least i bumped this one...
I haven't exactly been following this tread, but has anyone hear juiced on injectable HgH?
FuzzyKen
02-26-06, 11:24 PM
Several years ago there was a thread on another board stating that HGH would work as an enlargement agent.
Through strange circumstances and almost as a weird coincidence I fell into some HGH and because of that posting I "grabbed it" and did regular injections for about a month. I am sad to report that I had no gains in any manner from this and considered it a failure.
Fuzzy Ken
scubaaction
09-25-10, 11:41 PM
Im new and you guys talk about PE what is that. supra... u said to IM you if we want info on ifg and cialis... but you dont allow private Im's... i would like a site to get this stuff. what wrks the best for length and width gains...
REDZULU2003
09-13-11, 06:57 PM
Anyone tried anything like this since?
freeline
09-14-11, 04:51 PM
Anyone tried anything like this since?
tried it a little. igf lr3 that is but not enough to be conclusive.
i also tried a HGH Blast. This was for recomp reasons (Bodybuilding). The theory it to mimic pubertys release of HGH over a short sustained period. I used 140ius over 7 days. I also did heavy stretching and hanging during this period. Unfortunately nothing gained PE wise. But physique made great improvements..
You have to use IGF-1 or HGH for at least 6 months to start seeing the benefits
TylerVo
09-17-11, 11:37 AM
I might Run the IGF-1 By its self for the first month. I am only going to take the Arimidex once or twice a week. It is the god of estrogen antagonists
freeline
09-23-11, 12:19 PM
I might Run the IGF-1 By its self for the first month. I am only going to take the Arimidex once or twice a week. It is the god of estrogen antagonists
poor decisions. playing with your endocrine system like that will not end well.
doublelongdaddy
09-23-11, 04:12 PM
will this stuff effect hair growth?
Well guys great new, I am back on HGH
I will give you all the details.
This is what I am taking
Norditropin 5mg/1.5ml
2iu's a day before working out.
Just started today will keep you posted.
will this stuff effect hair growth?
Yes it will grow and thicken you hair
Yes it will grow and thicken you hair
What about HGH drops?
http://www.physicaladdictions.com/Muscle-Building/Natural-Hormone-Boosters/Trans-D-Tropin
This thing has some good recommendations!
http://www.youtube.com/watch?v=34JlATc7jnM&feature=results_main&playnext=1&list=PL0E14F334B9A82D2B
Looks like good stuff I will order some
Looks like good stuff I will order some
What will you order, i want to know are they selling placebo..
MikeShlort
11-12-11, 09:10 PM
Well guys great new, I am back on HGH
I will give you all the details.
This is what I am taking
Norditropin 5mg/1.5ml
2iu's a day before working out.
Just started today will keep you posted.
Did you have any penis enlargement results when taking HGH before?
MikeShlort
11-16-11, 12:12 AM
No
Try doing 4IU at a time.. I read that you were only doing 2 IU... Every where I read about HGH they recommend doing at least 4IU, even on the HGH manufacturer sites. I've even read in some bodybuilding forums that people will do the odd 10IU dose for a week or so straight to get it going then cut back gradually.
MikeShlort
11-16-11, 12:14 AM
Also, you are supposed to inject it right before sleep, on an empty stomach, and/or in the morning one hour before eating. You said you were injecting before workout, I think this is incorrect. GH is released during the first stage of sleep, and when on an empty stomach, more GH is released by the body, whether taking supplements or not. Check out some internet searches on the stuff and some bodybuilding/steroid forums are always full of people who know all about the stuff :). Let me know how it goes, I may start HGH in the future and will give you my feedback as well!
Forget everything written in this thread.
Use GH secretatogues instead of synthetic HGH.
Gh secretatogues will create a much bigger GH spike, and thats what we need. Synthetic HGH will also weaken your natural GH production, so you will need to use peptides anyways, to kickstart your system (like a PCT, post cycle therapy)
You dont want a, lets say for example, +2 spike for 7 hours or a +1 spike for 24 hours or a whole week. What you want is a +6 GH spike for 1 hour.
What we are talking about is (from most potent to least potent)
Hexarelin
GHRP-2
GHRP-6
Ipamorelin
Although Ipamorelin is the last, its still very potent, dont get fooled by that.
For a very great synergistic effect you want to stack it with CJC-1293 (widely known as CJC-1295 NON DAC). The one with DAC (Drug Affinity Complex) will cause GH bleed, a very low but very long lasting GH release. And since we want big, short G H spikes instead of this, forget about it. Its of no value for ANYTHING.
GH alone won't give you any gains, UNLESS you have high DHT levels and a lot of active androgen receptors in your corpus cavernosum.
So you want to boost DHT in there, locally via DHT gel/creme.
Only comercially available DHT gel is Andractim 2.5%.
GH wont give growth alone, but will augment the DHT's effects, synergy.
99% of all chemical PE stacks lack the enhanced GH levels.
Inject sub-q, but not in your penis, that wont do anything.
Then you will also need 7-Keto (DHEA) gel for cortisol antagonism.
DHT will give you some big cortisol problems. People dont pay attenton to that, so never do it without.
As simple as that:
DHT gel (for example Andractim 2.5%)
7-Keto DHEA gel
GH secretatogues (dont use HGH)
enhance parasymphatetic nervous system function
=
natural growth
Forget everything written in this thread.
Use GH secretatogues instead of synthetic HGH.
Gh secretatogues will create a much bigger GH spike, and thats what we need. Synthetic HGH will also weaken your natural GH production, so you will need to use peptides anyways, to kickstart your system (like a PCT, post cycle therapy)
You dont want a, lets say for example, +2 spike for 7 hours or a +1 spike for 24 hours or a whole week. What you want is a +6 GH spike for 1 hour.
What we are talking about is (from most potent to least potent)
Hexarelin
GHRP-2
GHRP-6
Ipamorelin
Although Ipamorelin is the last, its still very potent, dont get fooled by that.
For a very great synergistic effect you want to stack it with CJC-1293 (widely known as CJC-1295 NON DAC). The one with DAC (Drug Affinity Complex) will cause GH bleed, a very low but very long lasting GH release. And since we want big, short G H spikes instead of this, forget about it. Its of no value for ANYTHING.
GH alone won't give you any gains, UNLESS you have high DHT levels and a lot of active androgen receptors in your corpus cavernosum.
So you want to boost DHT in there, locally via DHT gel/creme.
Only comercially available DHT gel is Andractim 2.5%.
GH wont give growth alone, but will augment the DHT's effects, synergy.
99% of all chemical PE stacks lack the enhanced GH levels.
Inject sub-q, but not in your penis, that wont do anything.
Then you will also need 7-Keto (DHEA) gel for cortisol antagonism.
DHT will give you some big cortisol problems. People dont pay attenton to that, so never do it without.
As simple as that:
DHT gel (for example Andractim 2.5%)
7-Keto DHEA gel
GH secretatogues (dont use HGH)
enhance parasymphatetic nervous system function
=
natural growth
Great post, what BB forum are you on?
I'm on no BB forum, I'm on GTF and I was on datbrue, but I got banned for my Grow taller after growth plate fusion thread because there are only people left who dont know shit.
I'm going to try what I was writing in my last post since I will be on very high GH levels anyways for some HI formula, so why not get gains in height AND size.
duuudes, whats all this hgh and stuff? is there a better way i can understand this? i heard supras taking this stuff and wanted to know what stuff helps you get bigger? and also what is there that can make you taller?
are these safe to use and where can i get these from?
thanks
8incyclops
01-27-12, 02:02 AM
Bigger??? as in body size or penis size?? No getting taller posts are on diffrent body building forum by AlphaG dont know which sites tho
I'm on no BB forum, I'm on GTF and I was on datbrue, but I got banned for my Grow taller after growth plate fusion thread because there are only people left who dont know shit.
I'm going to try what I was writing in my last post since I will be on very high GH levels anyways for some HI formula, so why not get gains in height AND size.
I am taking the peprtides as well as GH, I am also on datbetrue
Aimingforthetop
01-27-12, 04:16 AM
duuudes, whats all this hgh and stuff? is there a better way i can understand this? i heard supras taking this stuff and wanted to know what stuff helps you get bigger? and also what is there that can make you taller?
are these safe to use and where can i get these from?
thanks
what is being discussed in this thread is steroids/hormones.
yes they can make the human body do amazing things. what supra is trying (as i understand) is to find one giving a good effect on the cock (making it bigger that is)
steroids and or hormones does have side effects. and taking them can have fatal consequenses.
however the mainstream media is demonizing it out of proportions.
its the usual: you have sex. you get aids and babys and then you die. kind of thing.
just this time: you take hormones. you get insane you kill everyone you love and then you die!!!!.
basically some companys in the US is making the drug tests they use. so people with too much power invest alot of money in these companies and then they make a big fuzz about the misuse of hormones and demands people to be tested. which then makes the companys who makes the tests. filthy rich, and they just so happened to invest in that.
the same goes with weed and other drugs.
im not saying: go take hormones. its safe.
but i woun't say it will kill you either.
as per usual the truth is somewhere in the middle.
if you try and do these things. do it on your own risk.
and make sure you do a SHITload of research first.
im 24. my dad got it from the doctors. and i intend to start taking it when im older.
when i get beyond 35 i wanna be god damn buff.
but right now i don't touch the stuff. however i do research it alot
celttank
01-27-12, 04:50 AM
How is the norditropin working out for you supra? I ordered some kigtropin from china recently. It will be my first cycle of hgh and i'm hopeing the stuff is good to go. Alot of fake shit going around lately so i'm a bit worried.
malehanger
01-27-12, 07:08 AM
You really have to be careful with GH. In fact, I would not order the stuff from overseas myself unless I was sure that my "source" was 100% legit and that would take testimonials from at least a couple people I knew in PERSON. I see guys talking to guys they "know" online on "check" forums and it just amazes me that they take their words for the gospel. GH and steroids are a huge profit business and as such are faked quite often. Hell, LOL you should see some of the names on these so called growth hormone variants. I've seen goofy shit like "thanktropin", "greattropin", "hugetropin". Etc.
MikeShlort
01-27-12, 07:11 PM
How is the norditropin working out for you supra? I ordered some kigtropin from china recently. It will be my first cycle of hgh and i'm hopeing the stuff is good to go. Alot of fake shit going around lately so i'm a bit worried.
I wouldn't buy anything from China, mainly because you are most likely paying for fake stuff. Talk to some guys at a gym/athletes/trainers and they'll probably be able to help.
rochout
02-16-12, 03:49 PM
so im very curious did hgh help you get bigger?
Miiiiiiighty
03-02-12, 04:25 AM
I'm on no BB forum, I'm on GTF and I was on datbrue, but I got banned for my Grow taller after growth plate fusion thread because there are only people left who dont know shit.
I'm going to try what I was writing in my last post since I will be on very high GH levels anyways for some HI formula, so why not get gains in height AND size.
Do you mean height improve by grow taller ? If so i'm interested to know more !
John_117
05-20-12, 07:33 AM
HGH will not make you taller if you are an adult and your growth plates have fused. If done at too large a dose and for too long you can get acromegaly. As far as the penis size I'm not to sure, but what I do know is that after about age 18-20 the androgen receptors in the penis become desensitized.
On a side note I'm amazed at how many years this thread has been commented on.
John_117
05-20-12, 07:37 AM
Also I will be starting GHRP-6 and CJC-1295 which increase HGH. I am also going to get back into PE and FR. I'll try to get back to you guys(crazy schedule) to see if it improves my results.
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