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dickerschwanz
07-26-12, 12:45 PM
Inspired from Kingsnakes trials and my own succes with a DMSO+Nascent Iodine solution I thought that it might make sense to start a thread where we can discuss what could or can work to increase our results with Penis Enlargement.

I will update this post whenever we find out something that works. X means the added substance(s) to the DMSO.

DMSO is an anti inflammatory solvent that carries everything that weights less then itself through the skin.
Many supplements who are ingested are not absorbed that efficient if at all.
Thus DMSO gives the possibility to transport substances that might help with penis enlargement to apply them directly into the skin and the penis.

I myself used DMSO+Nascent iodine in combination to treat scar tissue inside my penis(peyronies)
I grew in 1-2 months 0,2 inches in girth and my former weak erections have now a very good EQ. I feel like the scar tissue on my tunica has softened and allows for more expansion. Its directly related to my treatment with DMSO and Nascent Iodine.

(This stuff is not for starters)
Take care with DMSO as it carries everything lower then its own weight. This means also toxic stuff that comes into contact with dmso on your skin might move inside your body.

Powersnake12
07-26-12, 01:05 PM
DS,

Would you please go into detail regarding the benefits of iodine regarding your scar tissue?

What other benefits does it have?

Know the effect DMSO has to transport substances transdermally, what other substances would you use in regards to Penis Enlargement?

Thanks.

dickerschwanz
07-26-12, 02:16 PM
I have some male extra pills I didnt intent to eat as they produce mostly diarreha.
I'm now wondering if it might make sense to open them and dissolve them in DMSO to apply it directly to the dick.

Male extra has as ingridients:
- L-Arginine - Often used with DMSO, so it gets carried transdermal(through the skin). Arginine is directly involved in the collagen cycle
- Pomegrante as ellagic acid - I found some studies not related to the penis were pomegrante was used with DMSO. So it probably is absorbed.
- Zinc as aspertate - found several reports of zinc in combo with dmso but nothing about the aspertate.
- MSM - a form of DMSO itself.
- Cordyceps - Interesting find:
"Further-
more, an isolated extract of Cordyceps sinensis H1-A has
been shown to inhibit apoptosis induced by dimethyl sulfox-
ide (DMSO)"
Apoptosis is cell death. This might be usefull for clamping in dangerous territory ^^(again this is not for newbies)
- omega 3 fatty acid - couldnt find anything if that can be combined.
- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."
which means- >
"Protein oxidation: Proteins are also targets for free radicals. Oxidative
modification of proteins by reactive oxygen species (ROS) or reactive nitrogen
species (RNS) is implicated in the pathogenesis of various diseases. Oxidative
damage to a specific protein, especially at the active site, can induce a
progressive loss of a particular biochemical function. Several types of ROS-
induced protein modifications have been demonstrated (17), including the loss
of sulfhyryl (SH) groups, formation of carbonyls, disulphide crosslink,
methionine sulfoxide, dityrosine cross-links, nitro tyrosine, and glyoxidation
and lipid peroxidation adducts, among others. Alterations of signal transduction
mechanisms, transport systems, or enzyme activities have been shown (18).
Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "
Tough as MSM(a sort of dmso) is also in the male extra mix Im wondering if this as any health effects... ?
We might ask male extra for that. they shoudl know if msm/dmso + methionine can be combined.
So for now - > No combination of male extra pills with DMSO at least for me.

dickerschwanz
07-26-12, 02:28 PM
DS,

Would you please go into detail regarding the benefits of iodine regarding your scar tissue?

What other benefits does it have?

Know the effect DMSO has to transport substances transdermally, what other substances would you use in regards to Penis Enlargement?

Thanks.

Well, I cant go into chemcial details. Tough, reading about it a fair bit it is stable info that iodine reduces scar tissue with many first hand reports.
It also reduces fibrosis quote:"(hardening of the tissue due to the deposition of fibrin, similar to the formation of scar tissue)".
I used nascent iodine as it is "atomized" in some form which enables it to bind better to tissue/other cells.

Now I discovered that the scar tissue in my dick is much more pliable and softer. I also think that one plague seperated in two.
I for sure experienced a direct correlation between EQ and the application of dmso+iodine.(the blood couldnt fill properly due to the scar tissue and I guess the scar tissue now "gives" some space)
____

I would theoreticly use every substance that is said to help in growing more dick ^^. Thats what I would like to talk about in this thread ;)
I already did some research above and I hope that some of you guys chime in.
Hopefully in the end we know which substances are safe to use in combination with DMSO, which substances work how and when and if we can combine them in one solution.

doublelongdaddy
07-26-12, 02:28 PM
I have some male extra pills I didnt intent to eat as they produce mostly diarreha.
I'm now wondering if it might make sense to open them and dissolve them in DMSO to apply it directly to the dick.

Male extra has as ingridients:
- L-Arginine - Often used with DMSO, so it gets carried transdermal(through the skin). Arginine is directly involved in the collagen cycle
- Pomegrante as ellagic acid - I found some studies not related to the penis were pomegrante was used with DMSO. So it probably is absorbed.
- Zinc as aspertate - found several reports of zinc in combo with dmso but nothing about the aspertate.
- MSM - a form of DMSO itself.
- Cordyceps - Interesting find:
"Further-
more, an isolated extract of Cordyceps sinensis H1-A has
been shown to inhibit apoptosis induced by dimethyl sulfox-
ide (DMSO)"
Apoptosis is cell death. This might be usefull for clamping in dangerous territory ^^(again this is not for newbies)
- omega 3 fatty acid - couldnt find anything if that can be combined.
- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."
which means- >
"Protein oxidation: Proteins are also targets for free radicals. Oxidative
modification of proteins by reactive oxygen species (ROS) or reactive nitrogen
species (RNS) is implicated in the pathogenesis of various diseases. Oxidative
damage to a specific protein, especially at the active site, can induce a
progressive loss of a particular biochemical function. Several types of ROS-
induced protein modifications have been demonstrated (17), including the loss
of sulfhyryl (SH) groups, formation of carbonyls, disulphide crosslink,
methionine sulfoxide, dityrosine cross-links, nitro tyrosine, and glyoxidation
and lipid peroxidation adducts, among others. Alterations of signal transduction
mechanisms, transport systems, or enzyme activities have been shown (18).
Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "
Tough as MSM(a sort of dmso) is also in the male extra mix Im wondering if this as any health effects... ?
We might ask male extra for that. they shoudl know if msm/dmso + methionine can be combined.
So for now - > No combination of male extra pills with DMSO at least for me.


That is something I have never heard of, it is worth a try.

dickerschwanz
07-26-12, 03:09 PM
Maximumpills pills supplement:
- Epimedium Saggittum extract (20:1) 360mg
Is aparently a flavonoid and is soluable in DMSO.
- Catuaba Bark Extract (can be solved in dmso - http://www.sciencedirect.com/science/article/pii/S0006899308000346)
- Muira Pauma Extract

Antioxidant and neuroprotective activity

Muira puama is used by Amazonian peoples to prepare traditional remedies for the treatment of various central nervous system conditions, in which free radicals are likely to be implicated. A recent study examined the in vivo antioxidant effect of muira puama extract. Ageing mice (14 months) were treated (i.p.) with saline, DMSO (20%) or muira puama extrct (100mg/kg body weight), and the hippocampus, cerebral cortex, striata, hypothalamus and cerebellum dissected out 60 minutes later to measure antioxidant enzyme activities, free-radical production and damage to macromolecules. Muira puama administration reduced free-radical production in the hypothalamus, lead to significant decrease in lipid peroxidation in the cerebral cortex, striatum and hypothalamus, as well as in the carbonyl content in cerebellum and striatum. In terms of antioxidant enzymes, catalase activity was increased in the cortex, striatum, cerebellum and hippocampus, while glutathione peroxidase activity was increased in the hippocampus. This study suggests that muira puama contains compounds able to improve the cellular antioxidant network efficacy in the brain, ultimately reducing the damage caused by oxidative stress.3

An earlier study examined the neuroprotective properties of an orally administrated ethanol extract of muira puama using hippocampal slices from Wistar rats exposed to oxygen and glucose deprivation followed by re-oxygenation. The ischemic condition significantly impaired cellular viability, and increased free radical generation. In normal tissue, incubation with the muira puama extract (0.6 microg/ml) increased mitochondrial activity by 40%, without affecting free radical levels. In damaged tissue, incubation during and after oxygen and glucose deprivation significantly increased cellular viability. Additionally, at the same concentration, muira puama extract prevented the increase of free radical content induced by oxygen and glucose deprivation. In view of the fact that respiratory chain inhibition and increased generation of free radicals are major consequences of the ischemic injury, this study suggests that muira puama contains useful antioxidant and neuroprotective compounds.4
http://www.globalnaturalmedicine.com/ptychopetalum-olacoides/
Sounds good!

- Panax Ginseng Extract (soem studies where ti was dissolved in dmso)

we obtained Panax ginseng C.A. Meyer.
This study was designed to investigate the possible collagen production-promoting activities of Panax ginseng


In conclusion, the data acquired in this study demonstrate
that PGRE can induce the synthesis of Type I collagen

sounds good.

- Fructus Craetegi - Hawthorn berry(soluable)
- Gingko Biloba Extract

Ginkgo
A recent unpublished study reported that topical application of ginkgo diluted in 1% DMSO had an anti-inflammatory effect in the management of cellulites.
- Seman Cuscutae(nothing found)
- L -Arginine(already discussed, should work)

It sounds promising. I wil ltry to dissolve a capsule in DMSO and look what happens on a small patch of skin ^^

_______________________
It seems like most of this natural extracts are able to be dissolved in DMSO(remember DMSO is derived from trees)
I think most of the supplements are wasted when eaten and not fully used.
___________

dickerschwanz
07-26-12, 03:19 PM
That is something I have never heard of, it is worth a try.
Yes but dont forget this in the context(male extra into DMSO) you quoted:


- L-Methionine
It seems Methionine and DMSO should not be combined:
"For peptides which contain methionine residues the use of DMSO is not recommended because it
leads to methionine sulfoxide formation."
Which means as I understand Protein Oxidation. Which could mean:

Protein oxidation may be at least in part responsible for atherosclerosis, many
forms of cancer, ischemia-reperfusion injury and may also be associated with
aging "
Well this can be said of many things but why take a risk..on the other hand male extra mixes L-Methionine with MSM which is another form of DMSO.

Maybe it(mixing with l-Methionine) also inhibits the transdermal propertys of dmso. Tough I'm no expert on this so people who read all that stuff take it with a grain of salt.
(If you transport unknown stuff via DMSO into your body then its your own fault.)
_________
Next I'm checking out what it does with essential oils cause some essential oils might help too in some way..

Powersnake12
07-26-12, 03:25 PM
DS,

Thanks for the reply.

Do you experience and burning sensations when applying DMSO to your skin?

I have some 70%/30% DMSO/Aloe gel but have yet to try it on my dick.

dickerschwanz
07-26-12, 03:55 PM
DS,

Thanks for the reply.

Do you experience and burning sensations when applying DMSO to your skin?

I have some 70%/30% DMSO/Aloe gel but have yet to try it on my dick.

Yes the first times even with 70% dmso it burned in combo with iodine. Tough it was bearable. Now my dick kind of used to it.
The 99% with iodine burns for sure. Tough you can take it too.
The dmso aleo gel is top and you wont experience burning I guess as the aloe prevents this. Tough if you have small cuts it might still burn.

I read something prior that a guy put cayenne + dmso on his dick and it burned like hell but after that he got an erection to please his wife which he didnt get normaly. lol

dickerschwanz
07-26-12, 04:03 PM
Whats very important with this research is: where does the substance we move into the body is used. This means where is the receptor that the substance is docking onto.
If its in the brain and we apply it to the dick it makes no sense.

It might end up in the bloodstream and at the place where it needs to be at some time but keeping it local might make most sense.

For example L - tyrosin docks in the brain, on what I found with google till now. Tough, I'm not sure what dmso at the head does.
But many people with hair loss problems use dmso on their head daily on the other hand.

Hope some of you guys chime in into the discussion.

dickerschwanz
07-26-12, 05:04 PM
Ok excited lol

Mixed some dmso with the Maximumpills pills supplement(I think it came with the sg extender)
3 pills in an eyedropper glas. I filled in the same amount of dmso 99% solution. So half glass pills and the other dmso.
Shaked it and it got really hot.
Clamped 10 minutes while applying the solution. No burn whatsoever.

It did something in my body I think as I feel different like higher temeprature.
Feel good now and seems like my hang is fatter after the 10 minute(light)clamp then otherwise.

Will check for other indicators till tomorrow.

__________
Im not sure how I will proceed with these tests.
Just applying stuff I think is not harmfull and then checking for indicators like EQ, morning wood, size expansion when clamped.

dickerschwanz
07-26-12, 05:46 PM
Ok fuck this shit worked. Im sure. Got into the blood stream. Dont know if it reacted directly inside the dick(?). Guess there are some receptors needed.
Anyway I got heat and very intense feeling in my dick. Im also kind of dizzy. I didnt wanted to cum but got too focused on it lol.
And this was approx a 1/5 of a capsule. when I ate 2 of them it didnt had that influence on me.

Next time I run 3 applications. Should be more intense. Will also be interesting if there is a difference when I use it on my arm ^^

bjembe
07-26-12, 07:57 PM
Whats very important with this research is: where does the substance we move into the body is used. This means where is the receptor that the substance is docking onto.
If its in the brain and we apply it to the dick it makes no sense.


This is a very important point you have raised, as I was thinking the same. It will be in no use to us or minimal efficiency if the substance we are transporting via DMSO is unable to act as there maybe no receptors in the localized area of the dick. The receptors might be in gastrointestinal tract, pancreas, brain... and there maybe a whole chain of chemical pathway before it reaches the desired effect that we want. I guess doing in depth research on each compound we intend to put in our body is very important, both for safety and efficiency.

Good thread dicker.

About DMSO on the head, I do not think that will be efficient as it will have to penetrate the thick skull before it gets into the soft tissue. For the folks out there with really "thick skull" it would be a waste of time :)

makemebig
07-27-12, 02:00 PM
I have been applying DMSO with Lugol's iodine daily for a year to prevent scaring from my Trimix injections. So far, there has been no scaring, but it is still a little early for scar tissue to start forming.

I also apply it to my glans to reduce discoloration from vacuum applications (pumping and VacExtende). Discoloration definitely dissipates a lot quicker when the DMSO solution is used. I recently started applying Vitanin D oil first.

I have also been applying it to a wart on my wrist which has been reduced in size by about 50%.

doublelongdaddy
07-28-12, 03:58 PM
I also apply it to my glans to reduce discoloration from vacuum applications (pumping and VacExtende). Discoloration definitely dissipates a lot quicker when the DMSO solution is used. I recently started applying Vitanin D oil first.


Wow, so you have noticed a difference in it's effectiveness discoloration compared to not using it?

dickerschwanz
07-29-12, 07:30 AM
Wow, so you have noticed a difference in it's effectiveness discoloration compared to not using it?

I can definately say that using DMSO with iodine will reduce discoloration.
I think it does it though peeling the skin but also in freeing the iron deposits in the skin in opening the skin barriers.

dickerschwanz
07-29-12, 07:41 AM
Serraptase:

Serratiopeptidase breaks down collagen and fibrin. It can help the body "clean out" broken tissue in bones, muscles, tendons, and ligaments. It is especially useful for breaking down fibrin. This helps the body dissolve blood clots. That can be very helpful in healing bruises. And it prevents the formation of scar tissue so that joints retain their range of motion as they heal.

____________
(Topical formulations of serratiopeptidase: Development and pharmacodynamic evaluation)
Only IPM and DMSO were found to be effective in combinatino with seraptase in concentrations over 50%(dmso).
____________
Serrapeptase, like aspirin, is both anti-inflammatory and anticlotting; unlike aspirin, however, serrapeptase can melt through existing fibrous deposits
____________
Serraptase seems like a good thing for Penis Enlargement.

Its an enzyme so it shoudl work, to my understanding, directly on the cells.

dickerschwanz
07-29-12, 08:00 AM
Hyaluronic acid

Hyaluronic acid ( HA, also known as hyaluronan) is an essential building block that is naturally present in the human body. (e.g. as a shock absorber in the knees) Among its several functions it is known to stimulate the production of collagen. It is also claimed to improve natural cell repair,
....
"in adult and late gestation fetal wound healing, removal of HA results in fibrotic scarring. Though the exact role of HA in skin scarring is still under investigation, based on all the facts that have been observed, it must be a great contributor to the less fibrous scarring."
"hyaluronic acid content in fetal wounds (these wounds heal without scar formation) is higher than that in adult wounds, which suggests that HA may, at least in part, reduce collagen deposition and therefore lead to reduced scarring"
...
_____
Dmso and hyaluronic acid was tested together in some studies so it can be mixed.

dickerschwanz
07-29-12, 09:22 AM
On DMSO and its infleunce on Collagen and smooth muscle:


Prolonged exposure of cultured arterial smooth muscle cells to 1% dimethyl sulfoxide (DMSO) resulted in a remarkable increase in cytoplasmic microtubules and an appearance of bundle-like aggregates of microtubules associated with ribosomes
http://www.ncbi.nlm.nih.gov/pubmed/3549003
___________
http://www.cartage.org.lb/en/themes/sciences/zoology/animalphysiology/anatomy/animalcellstructure/Microtubules/Microtubules.htm
Microtubules form part of the cytoskeleton that gives structure and shape to a cell, serve as conveyor belts moving other organelles through the cytoplasm, are the major components of cilia and flagella, and participate in the formation of spindle fibers during cell division (mitosis). Microtubules can function individually or join with other proteins to create larger structures (e.g. cilia). These filaments are composed of linear polymers of tubulin, which are globular proteins, and can increase or decease in length by adding or removing tubulin proteins.

These straight, hollow cylinders are found throughout the cytoplasm of all eukaryotic cells (prokaryotes don't have them) and perform a number of functions.

__________
As I understand it till now, the microtobules are important to the cytoskeleton which also is important for the building of collagen structures.
This could mean that DMSO helps in building new collagen structures. These should be of the healthy kind which we might ensure with adequate enzymes and vitamins.
Tough this is only my amateur understanding.
__
Oner point that worries me a bit is the following quote:
[http://www.ncbi.nlm.nih.gov/pubmed/3597282]
"The growth of bovine aortic smooth muscle and endothelial cells was studied after exposure to dimethyl sulfoxide (DMSO) or its major metabolite, dimethyl sulfone (DMSO2). Both compounds caused a dose-dependent inhibition of cell growth as determined by [3H]thymidine incorporation and by counting the number of cells with time of exposure in culture.
..
It is concluded that the growth of smooth muscle cells was similarly inhibited by DMSO and DMSO2, but that smooth muscle cells were more susceptible than endothelial cells to the growth inhibitory effects of these compounds."

-- This states that bovine smooth muscle growth is inhibited under the influence of DMSO...
___
also:
"Dimethyl Sulfoxide Inhibits Tissue Factor Expression, Thrombus Formation, and Vascular Smooth Muscle Cell Activation"
________
In a follow up study:
"Inhibitory effect of dimethyl sulfoxide on the proliferation of cultured arterial smooth muscle cells: relationship to the cytoplasmic microtubules."
..
"Our preliminary study has shown that dimethyl sulfoxide (DMSO) has an inhibitory effect on the proliferation of cultured arterial smooth muscle cells and promotes phenotypic modulation from the synthetic state to the contractile state. In the present study we have examined the effect of DMSO with special attention to relationship between cell growth and cytoplasmic microtubules."
..
" These results suggest that DMSO inhibits DNA synthesis of cultured smooth muscle cells by stabilizing cytoplasmic microtubules."
_________________________
This might mean that using DMSO to expand and heal collagen is very usefull while it isnt for smooth muscle.
This might give some connection to the TGC Theory which states simplified that you have to concentrate on smooth muscle exercises or Tunica exercises to grow the whole dick. (smooth muscle fills the space that the tunica gives)
-------
This study on the other hand sounds good for smooth muscles.
http://www.ncbi.nlm.nih.gov/pubmed/2652978
"Synthetic activity of collagen types was examined in cultured arterial smooth muscle cells during modulation from synthetic to contractile phenotype by treatment with dimethyl sulfoxide (DMSO). Smooth muscle cells of rabbit thoracic aorta cultured with a 1% supplement of DMSO for 8 days (DMSO group) predominantly exhibited cellular features of the contractile type with abundant microfilaments and a distinct basement membrane. "
..
"Type analysis of the collagenous protein by SDS-PAGE and subsequent fluorography disclosed a markedly increased ratio of type IV/I collagen*1 and a slightly increased type V/I collagen ratio, as compared with those of controls. A decrease of type III collagen production in DMSO-treated cells probably due to their lower cell density was also recognized"
...(*1 does this mean the type IV or the typoe I did go up?)
___________
http://www.ncbi.nlm.nih.gov/pubmed/3440294
-> DMSO has influence in upping type IV collagen which we dont want(we want type 1 or two)
quote:
"Such an enhancement of type IV collagen synthesis appears to be expressed as a result of the phenotypic changes of smooth muscle cells to the contractile state modulated by DMSO."
_________
Well I hope someone can follow my thoughts and has some ideas..

DMSO sure helps but I want to find out when and where it helps best. If it inhibits smooth muscle grow then it might not be usefull for everyday application.

dickerschwanz
07-29-12, 10:04 AM
DMSO + smooth muscle research:

http://www.ncbi.nlm.nih.gov/pubmed/21967314

Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.

http://en.wikipedia.org/wiki/Icariin
( The compound is derived from several species of plants in the Epimedium family, which are commonly known as Horny Goat Weed or Yin Yang Huo.[)

->"Untreated diabetic animals had decreased smooth muscle/collagen ratio and endothelial cell content in the corpora cavernosa; treatment with icariin partially attenuating these effects."
"Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats."

dickerschwanz
07-29-12, 10:19 AM
DMSO + smooth muscle research:

http://www.ncbi.nlm.nih.gov/pubmed/21967314

Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.

http://en.wikipedia.org/wiki/Icariin
( The compound is derived from several species of plants in the Epimedium family, which are commonly known as Horny Goat Weed or Yin Yang Huo.[)

->"Untreated diabetic animals had decreased smooth muscle/collagen ratio and endothelial cell content in the corpora cavernosa; treatment with icariin partially attenuating these effects."
"Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats."

DMSO in- creased the response of the smooth muscle of the stomach to both muscle and nerve stimulations.
(http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34885.x/abstract)

Which in turn might mean that DMSO helps when training the smooth msucles.
I think that the DMSO wont be forever in the tissue so influence on the inhibition of smooth muscle proliferation(growth) might not be present after the dmso is gone.

doublelongdaddy
07-29-12, 04:16 PM
How would it effect smooth muscle? That is where I am stuck???

dickerschwanz
07-29-12, 08:48 PM
How would it effect smooth muscle? That is where I am stuck???
Me too.

wow anyone ever got a big post destroyed by a automatic windows update?
Whatever

http://en.wikipedia.org/wiki/Smooth_muscle_tissue

In short: DMSO pushes the smooth muscle to "grow" or "make ready" stuff that is contractory (actin) muscle cell stuff. The contractory stuff is in ratio 2:1 to 10:1 found(ratio towards myosin, the opposite in smooth muscle tissue). While it is kind of fixed with other muscles.
This is cause of http://en.wikipedia.org/wiki/Hyperplasia Hyperplasia. Smooth muscles divides into new smooth muscle while other muscles just expand.

This might be a problem as the penis needs to relax to fill with blood. So a too high ratio might give problems there.
On the other hand I guess everyone coudl be capable of pushing enough blood/relaxation into the dick via reverse kegels.


A smooth muscle is excited by external stimuli, which causes contraction

The contractile function of vascular smooth muscle also regulates the lumenal diameter of the small arteries-arterioles called resistance vessels, thereby contributing significantly to setting the level of blood pressure. Smooth muscle contracts slowly and may maintain the contraction (tonically) for prolonged periods in blood vessels, bronchioles, and some sphincters. Activating arteriole smooth muscle can decrease the lumenal diameter 1/3 of resting so it drastically alters blood flow and resistance. Activation of aortic smooth muscle doesn't significantly alter the lumenal diameter but serves to increase the viscoelasticity of the vascular wall.

Dont know what the conclusion from the above is but I think it describes what happens when there is more or less contractile stuff(which is pushed by DMSO) in the penis.
I think more contractory stuff means more power to hold blood inside. The relaxation or filling of the smooth muscles with blood can be done by kegels(reverse kegels) or other strong enough stimuli(woman, porn).
Weak EQ might mean that smooth muscle is not "strong" enough. Tough, Im not sure about this..just trying to add 1+1..


Relaxation
The phosphorylation of the light chains by MLCK is countered by a myosin light-chain phosphatase, which dephosphorylates the MLC20 myosin light chains and thereby inhibits contraction.[2] Other signaling pathways have also been implicated in the regulation actin and myosin dynamics. In general, the relaxation of smooth muscle is by cell-signaling pathways that increase the myosin phosphatase activity, decrease the intracellular calcium levels, hyperpolarize the smooth muscle, and/or regulate actin and myosin dynamics.
Myosin is the opposite of Actin (the contractile stuff). Less Myosin light chains mean maybe less ability to relax?
the ratio can be anything between 2:1 and 10:2 while the ratio is kind of set with other muscles.

I think the ratio is very important.
Question is now:Which ratio gives most function and growth(diameter)? or does it really matter? And how is this connected to the kegel muscles.... checking tomorrow. open for any idea.

For me a good indicator is that contractory stuff(actin) is always in bigger ratio there(2:1 up to 10:2). So for the smooth muscle there is always more actin. So for me it makes sense that more actin means better smooth muscle.
But we need myosin to grow too so we have more room for the actin stuff to fill between the myosin chains.

smerc
07-29-12, 09:03 PM
Dicker. You might look over, " http://www.mattersofsize.com/forum/showthread.php?66865-IMPORTANT-Everyone-Should-Read-This!! " if you haven't already.
There are a few mentions of PABA/DMSO/MSM and there is also a preformulated product out there(think the link is on page 2).

The DMSO discussions are very interesting. Chempe/pegym/ & a few others have some decent discussions as well for anyone also interested(at least in terms of transdermal iodine/potaba).

dickerschwanz
07-29-12, 09:16 PM
thanks smerc. will look through it. yes there is already some stuff in Penis Enlargement community about dmso. Tough , its very scattered and anectodal and I would like to have it all nailed down which I hope this thread will help with.

________

Niacine + DMSO

Did found nothing about the combo (up to g page 5) but the flsuh effect should show if its possible...(tough there is a niacin without flush properties)

DMSO+Niacine+X flushed thorugh a clamped dick sounds like win.
Nicotinamide is soluable in DMSO!
http://www.tocris.com/dispprod.php?ItemId=280736#.UBXvqKM2eUk

MikelB
07-30-12, 03:22 AM
There is a transdermal nitric oxide gel already called HFR that uses some proprietory solvent to pass through skin. I have tried it and it doesn't seem to get the nitric oxide to where you want it, i.e the muscle tissue of the penis. There are too much stuff under the skin for the stuff to work.
I was just wondering if insect venoms mixed with DMSO could be used for localized swelling. If it doesn't kill you, it would be a blast if it did work even temporarily.

dickerschwanz
07-30-12, 08:05 AM
There is a transdermal nitric oxide gel already called HFR that uses some proprietory solvent to pass through skin. I have tried it and it doesn't seem to get the nitric oxide to where you want it, i.e the muscle tissue of the penis. There are too much stuff under the skin for the stuff to work.
I was just wondering if insect venoms mixed with DMSO could be used for localized swelling. If it doesn't kill you, it would be a blast if it did work even temporarily.

The best solvent seems to be DMSO. The great thing is that DMSO itself has many beneficial effects.

Look at what I found:
http://www.ncbi.nlm.nih.gov/pubmed/9334655


RESULTS:
DMSO acutely increased reflex firing of pelvic nerve efferent axons, decreased bladder capacity and also increased neuronal c-fos expression in spinal cord regions that exhibit c-fos expression after chemical activation of capsaicin-sensitive bladder afferents. DMSO, like capsaicin, also directly released nitric oxide (NO) from both dissociated dorsal root ganglion neurons and from isolated strips of urinary bladder.
CONCLUSIONS:

These results suggest that DMSO induced stimulation of bladder afferent pathways and NO release from afferent neurons may be a reflection of the initial event in the desensitization of nociceptive pathways in the lower urinary tract (LUT).
DMSO itself pushes the penis and the bladder to release NO.

Capsaicin too:
http://www.earthclinic.com/CURES/erectile-dysfunction.html#CAYENNE
So it seems soluable in DMSO at least in the form of cayenne(lol)

Yeah it works alright! I read comments here and tried to pursued my sweet hubby to try cayenne although he despises anything hot... I suggested DMSO and cayenne applied directly to the big conductor... He reluctantly agreed. Train wreck! I over applied and sent him running for the shower! After I googled a solution... I offered milk and mayo to ease the pain... I felt awful... He may never try my home remedies again..... He came back to bed... Fully dressed in pjs... So I thought our night was over... Twenty minutes later he began to remove clothing... His and mine! I have never felt him so full of life!!!! He remained aroused throughout several posit$&?! This was challenging before cayenne... All I can say is thank you... The transfer of cayenne heat added lots of spice to the end of my evening too, I was ready for ice! Thanks to this great site!!!!!!!"

So I wouldnt do it cause this stuff burns sure like hell but maybe there is some capsaicin form that doesnt burn like cayenne.

L-Arginine is also a nitric oxide "pusher".
If your body is capable of producing the stuff on itself with the building blocks then this must be used first.
There are reports that using an final/endproduct that the body on itself produces will end up with decreased sensivity to it as the body stops producing it on itself.

Bee venom I would be carefull if you use too much as DMSO might distribute it into the whole body.. and how would you get that stuff in a measurable form?

Here they used Bee Venom together with DMSO
http://sbms.ccmu.edu.cn/extra/col1/1193047177.pdf


During the whole process of the experiments, a volume
of 50 Al saline containing 0.2 mg bee venom (BV), 50 Al
100% dimethyl sulfoxide (DMSO), and a single dose of
propofol (0.5 Ag of 99.99% 2, 6-diisopropyl phenol
dissolved in 50 Al DMSO) was subcutaneously injected
into the posterior surface of one hind paw, respectively
Tough I cant workout if the BV did do anything..

doublelongdaddy
07-30-12, 11:31 AM
Bee venom


There are two things that increase the size of my penis by double, bee stings and horses:) Unfortunately the same thing happens to my lips and eyes:)

dickerschwanz
07-30-12, 01:28 PM
Carnitine / Lysine

http://www.mail-archive.com/silver-list@eskimo.com/msg109702.html

One protocol we have found to be particularly effective
is the employment of lysine (many use the ointment applied topically) taken at
approximately 300 mg daily, together with the topical use of a lysine/DMSO
solution. The favored (by us) solution strength is 20% DMSO (by volume) mixed
with a super-saturated solution of lysine......applied to the blisters

___________

lysine converts to carnitine in the presence of vitamin C. lysine is cheap, carnitine is expensive.

dickerschwanz
07-30-12, 01:30 PM
L-Citruline converts to -> L-arginine

I did not know that...cool. Kinda like how L-citrulline converts to L-arginine and increases plasma L-arginine levels 4 fold greater that L-arginine itself.
_________________

While L-arginine may increase NO Nitric Oxide short term, it
can also increase urea which can increase uric acid. L-citrulline can increase NO for a much longer period of time
apparently without increasing uric acid. A clinical study reported good results with men with ED using 1500 mg of
L-citrulline daily. L-citrulline seems to work better if combined or taken with malic acid.
____
coudlnt find any hint on L-citrulline together with dmso.

____________
DMSO destroys arginine while ongoing hydrolisis(probably smooth muscle hydrolosis is affected too, but we want hydrolisis anyway)
http://www.aaccnet.org/publications/cc/backissues/1973/Documents/Chem50_309.pdf
Hm dont know what this means now.

At least it seems to transport via DMSO:
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Product_Information_Sheet/b4875pis.Par.0001.File.tmp/b4875pis.pdf

L-arginine 4-nitroanilide hydrochloride(tough this is a variation)
Storage/Stability
A solution in DMSO (containing a small portion of
ethanol) is stable for about one week at room
temperature.

This talks about L-glutamine, L-arginine, L-lysine in combination with DMSO:
http://scholarsresearchlibrary.com/APR-vol1-iss4/APR-2010-1-4-82-88.pdf

I dont understand the conclusion but it seems they all dissolve in DMSO.

Arginine:
http://www.ncbi.nlm.nih.gov/pubmed/8992957
Also not clear what happened with arginine here, for me at least.
___________________
Amino acids + DMSO:

Found this small mentioning:
http://dwb.unl.edu/Teacher/NSF/C08/C08Links/pps99.cryst.bbk.ac.uk/projects/gmocz/fluor.htm

*DMSO = dimethyl sulfoxide, an organic solvent for amino acids and peptides.
-> sounds good for dmso in general in relation to amino acids and peptides(some of the stuff we want to transport is in this range)
_____________
This sounds promising:
Good stuff-must read:
https://data.epo.org/publication-server/getpdf.jsp?pn=2324838&ki=A1&cc=EP

In one embodiment, the invention comprises
the use of a composition comprising dimethylsulfoxide
(DMSO) in the preparation of a medication for the treatment
of stroke or brain injury, wherein said composition
additionally comprises one or more of the following: Larginine
and urea. About 1.0 to 8.0 grams of L-arginine
may be dissolved in a DMSO solution. DMSO may be
provided in a concentration of about 20% to about 40%.
In one embodiment, a dose of 70 grams of DMSO is used.
About 20% to about 60% urea can be used. In one embodiment,
a combination (e.g., a solution) of about 50%
DMSO and 50% urea is provided.
+
Together, DMSO and arginine may
have a combined, additive, or synergistic effect. In some
embodiments, DMSO and arginine (or NO) act on different
receptors or pathways to increase blood flow more
than either of the compounds administered alone. In other
embodiments, DMSO and arginine (or NO) act on the
same receptors or pathways to increase blood flow.
+
In other embodiments, DMS and L-arginine
are provided along with one or more of the following:
fructose 1,6-diphosphate, L-lysine, L-aspartate, urea,
DMSO, MSM, and other DMSO metabolites.
+Because arginine is the immediate precursor of
NO, urea, ornithine and agmatine, in some embodiments,
NO, urea, ornithine and agmatine are used in addition to
or instead of L-arginine in several of the compositions
described herein. Because arginine is synthesized from
citrulline, citrulline may be used in addition to or instead
of L-arginine in several of the compositions described
herein. Other forms of arginine, other than the L isomer
may also be used. The compositions described herein
may comprise nitric oxide synthase to facilitate the production
of NO from arginine.
+
As discussed above, L-arginine given as a continuous
intravenous infusion was able to reduce the levels
of endothelin-1, one of the most powerful vasoconstrictors
known and also lowered the serum levels of
asymmetric dimethylarginine (ADMA), an endogenous
inhibitor of eNOS. L-arginine combined with L-aspartate
or L-lysine can increase its peak levels in physiological
conditions such as an increase in growth hormones and
bone metabolism. It is therefore anticipated that the addition
of L-lysine and /or L-aspartate to L-arginine should
increase the efficacy of this amino acid in traumatic or
degenerative brain conditions, according to several embodiments
of the invention.
+
In one embodiment, the present invention comprises
a composition comprising DMSO and L-arginine,
DMSO and urea, or DMSO, L-arginine, and urea. In other
embodiments, the present invention comprises a composition
comprising DMSO, L-arginine, and additional
compound selected from the group consisting of one or
more of the following: fructose 1,6-diphosphate, L-lysine,
L-aspartate, and urea. In one embodiment, a synergistic
effect is obtained when DSMO and L-arginine are combined
with these additional compounds.
+In another embodiment, the invention comprises
a DMSO solution and one or more of the following: Larginine,
fructose 1,6-diphosphate, L-lysine, L-aspartate,
and urea. In one embodiment, a synergistic effect
is obtained when DSMO is combined with these additional
compounds. In one embodiment, about 200 to 900
mg of L-lysine is dissolved in (or otherwise combined
with) the DMSO solution. In another embodiment, about
100 to 1,200 mg of the L-aspartate is dissolved in (or
otherwise combined with) the DMSO solution.
+
In one embodiment, the invention provides a
pharmaceutical formulation comprising DMSO, L-arginine,
and L-lysine. In one embodiment, the invention
comprises a pharmaceutical formulation comprising DMSO
and L-lysine. In another embodiment, one or more
additional amino acids are included.

Make sure to check the picture at page 11/17 it shows how proliferation is done in the body..
http://www.faqs.org/patents/imgfull/20090312273_01 <- same picture
-> So this product, which I assume had some testing, clearly states arginine is applicable in DMSO.
Not only arginine but also other susbtances that may help in increasing penis size. In the above study it is talked about the influence on the brain. Tough at elast we know now that dmso can be combined with other substances what in turn can also increase the effect.
http://www.faqs.org/patents/app/20090312273 <- also good summary of the above.

This is done by a guy named De la Torre, Jack. He has soem stuff i nthe ent about DMSO so I guess he knows what he is talking about.
http://www.lef.org/magazine/mag2007/jul2007_cover_dmso_01.htm
<.great article

___
I think this all sounds promising.
Give the body the nutrients necessary for the cycle to complete. Smaller amounts are possible through the use of DMSO as it doesnt need to survive the stomach. Questions are now on where to apply? Is the whole cycle (http://www.faqs.org/patents/imgfull/20090312273_01) happening directly in the penis?
If so then applying dmso with the building blocks for errections and growth in combination with exercise is very easy.

I think applying the stuff directly to the dick and maybe clamping it off to let it concentrate i nthe dick localy might sounds promising. There are more substances to check for. And then once we have a good index we need to think about in which concentrations, when and how often to apply it.
Some stuff might be best for recovery for the night or rest days while some might aid with the exercises directly.

dickerschwanz
07-30-12, 01:31 PM
Fiansteride(in relation to producing DHT naturaly):
http://en.wikipedia.org/wiki/Finasterid
soluable in DMSO.
Would be interesting to find out non prescription/natural product that does similar stuff.
Basicly it is this stuff:
http://en.wikipedia.org/wiki/5%CE%B1-reductase

Finasteride is synthesized from progesterone:
http://en.wikipedia.org/wiki/Progesterone



"An additional source of progesterone is milk products. After consumption of milk products the level of bioavailable progesterone goes up"
+
"In at least one plant, Juglans regia, progesterone has been detected.[7] In addition, progesterone-like steroids are found in Dioscorea mexicana. Dioscorea mexicana is a plant that is part of the yam family native to Mexico.[8] It contains a steroid called diosgenin that is taken from the plant and is converted into progesterone.[9] Diosgenin and progesterone are found in other Dioscorea species as well.

Another plant that contains substances readily convertible to progesterone is Dioscorea pseudojaponica native to Taiwan. Research has shown that the Taiwanese yam contains saponins — steroids that can be converted to diosgenin and thence to progesterone.[10]

Many other Dioscorea species of the yam family contain steroidal substances from which progesterone can be produced. Among the more notable of these are Dioscorea villosa and Dioscorea polygonoides. One study showed that the Dioscorea villosa contains 3.5% diosgenin.[11] Dioscorea polygonoides has been found to contain 2.64% diosgenin as shown by gas chromatography-mass spectrometry.[12] Many of the Dioscorea species that originate from the yam family grow in countries that have tropical and subtropical climates.[13]"
http://en.wikipedia.org/wiki/Progesterone#Biosynthesis
__

In mammals, progesterone (6), like all other steroid hormones, is synthesized from pregnenolone (3), which in turn is derived from cholesterol
http://en.wikipedia.org/wiki/Pregnenolone
also:
Progesterone in turn (see lower half of figure to the right) is the precursor of the mineralocorticoid aldosterone, and after conversion to 17-hydroxyprogesterone (another natural progestogen) of cortisol and androstenedione. Androstenedione can be converted to testosterone, estrone and estradiol.
->http://en.wikipedia.org/wiki/Aldosterone
->http://en.wikipedia.org/wiki/Aldosterone#Stimulation
<- interesting ->

"increase in plasma angiotensin II, ACTH, or potassium levels, which are present in proportion to plasma sodium deficiencies. (The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which opens the voltage-dependent calcium channels.) The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by the hormone renin. Potassium levels are the most sensitive stimulator of aldosterone."
Pottasium stimulates this stuff.
The plasma concentration of potassium
The amount of aldosterone secreted is a direct function of the serum potassium [12][13] as probably determined by sensors in the carotid artery.[
+
ACTH
ACTH, a pituitary peptide, also has some stimulating effect on aldosterone, probably by stimulating the formation of deoxycorticosterone, a precursor of aldosterone
ACTH is also related to the circadian rhythm in many organisms. The half-life of ACTH in human blood is about ten minutes.
(it is produced mostly in the morning..maybe a little hint for a morning workout to use DHT?-> remember all this stuff is related to DHT production)

+
Aldosterone and corticosterone share the first part of their biosynthetic pathway
http://en.wikipedia.org/wiki/Corticosterone

One example of a release pathway relates to UV-B stimulation on the skins of certain amphibians such as the Rough-skinned Newt, Taricha granulosa; this trigger seems to cause the internal generation of corticosterone in that species. (NOTE:amphibians)
___________
This all seems cluttered till now all over the place but I have the feeling there are some connections and the picture of the puzzle will come through.

dickerschwanz
07-30-12, 01:33 PM
soem about smooth muscle
____________
Zinc + dmso
http://www.ncbi.nlm.nih.gov/pubmed/9397984

We previously showed that primary rat hepatocytes plated on a rat-tail collagen coated dish and fed a chemically-defined medium supplemented with 2% dimethylsulfoxide (DMSO) can be maintained in a well-differentiated, non-replicating state for periods of several months. In this study, we show that the addition of copper, iron, and zinc to the DMSO-containing chemically defined medium induced DNA synthesis and cell replication during the first two months in culture without loss of hepatic differentiation..
We conclude that under these specific nutritive conditions, primary rat hepatocytes proliferate and, with time, begin to form duct-like structures with altered gene expression and ultrastructural properties.
http://www.sciencedirect.com/science/article/pii/S0277538700869831
http://www.ingentaconnect.com/content/dav/aaua/1999/00000085/00000006/art00009

". The addition of electrolyte (zinc acetate) to aqueous solutions of nonelectrolyte (DMSO) do not destroy the structure created by an interaction: water-DMSO molecules"
http://researchspace.csir.co.za/dspace/bitstream/10204/4915/1/Du%20Plessis7_2010.pdf

http://www.chempap.org/file_access.php?file=403a323.pdf
->

Almost all our previous studies were concerned with nitrates as these are highly
soluble in both DMSO and water and give us a possibility to study the volumetric
and transport properties of solutions over the composition range in which the
number of particles of the electrolyte is comparable with that of solvent.
..
A comparison of highly concentrated solutions of ZnCl2 and Zn(N03)2 in
DMSO and water shows that the two electrolytes have opposite tendencies to
complexation and contact ion pair formation in DMSO and H20 solutions.
-> dont knwo what this indicates. Tough there seem to be different reaction to DMSO in the different forms of one supplement(in this case zinc)
-> So we also need to find out which form of the supplement is best use..

another info about zinc:

Zinc,[5] azelaic acid,[5] ?-sitosterol,[6] certain unsaturated aliphatic fatty acids such as gamma-linolenic acid, alpha-linolenic acid, linoleic acid, and oleic acid,[7] and a variety of polyphenols[8] have been found to inhibit 5?-reductase activity
http://en.wikipedia.org/wiki/5-alpha-reductase_inhibitor
http://en.wikipedia.org/wiki/5-alpha-reductase_inhibitor#Herbs
hm:

5-alpha-reductase inhibitors such as finasteride (brand names Proscar and Propecia), dutasteride (brand name Avodart), bexlosteride,izonsteride, turosteride, and epristeride are antiandrogenic as they prevent the reduction of testosterone to dihydrotestosterone (DHT).[16]DHT is 3-5 times more potent than testosterone or other androgens (except in skeletal muscle tissue, where testosterone is the main androgen). They are unique because they do not counteract the effects or production of other androgens other than DHT. Dihydrotestosterone is necessary for development of both external male sex organs and the prostate.
http://en.wikipedia.org/wiki/Antiandrogen
<-So we want to avoid that stuff!
http://en.wikipedia.org/wiki/Androgen

Muscle mass
Males typically have more skeletal muscle mass than females. Androgens promote the enlargement of skeletal muscle cells and probably act in a coordinated manner to function by acting on several cell types in skeletal muscle tissue.[4] One type of cell that conveys hormone signals to generating muscle is the myoblast. Higher androgen levels lead to increased expression of androgen receptor. Fusion of myoblasts generates myotubes, in a process that is linked to androgen receptor levels.[5]
myotubes(!) we had that earlier in the smooth muscle research I think.
http://en.wikipedia.org/wiki/Myoblasts

Each myocyte contains myofibrils, which are very long chains of sarcomeres, the contractile units of the cell. A cell from the biceps brachii muscle may contain 100,000 sarcomeres.[3] The myofibrils of smooth muscle cells are not arranged into sarcomeres. The sarcomeres are composed of thin and thick filaments. Thin filaments are actin filaments, whereas thick filaments consist of an arrangement of myosin proteins. The sarcomere does not contain organelles or a nucleus. Individual muscle fibrils are surrounded by endomysium.
-> actin + myosin which are the two building blocks of smooth muscle.

dickerschwanz
07-30-12, 01:34 PM
smooth muscle research:
Interleukin 6
http://en.wikipedia.org/wiki/Interleukin-6

-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.[3] It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery
Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine
-> means muscle work produces interleukin 6.(this might give also some reason for Penis Enlargement after exercise)
http://ajpheart.physiology.org/content/260/5/H1713.abstract

We have investigated the effect of interleukin 6 (IL-6) on the growth of vascular smooth muscle cells (VSMC) isolated from rat aortas.
These results support the premise that IL-6 is released by VSMC in an autocrine manner and promotes the growth of VSMC via induction of endogenous PDGF production.

Smooth msucle growth inhibition(to avoid)
http://ajpcell.physiology.org/content/267/5/C1405.abstract

Recent studies indicate that nitric oxide (NO) and guanosine 3',5'-cyclic monophosphate (cGMP) may inhibit the proliferation of vascular smooth muscle cells (SMC) in vitro.
AS already in a previous psot seen, there might be some correlation with NO and smooth muscle which inhibts growth(which might give indicators when to use nitric oxide)

__________
homocystein and smooth msucle growth:
http://www.ncbi.nlm.nih.gov/pubmed/20857402

Homocysteine may accelerate progression of atherosclerotic lesions by promoting SMC (smooth muscle)proliferation.(another indicator where something might be better used locally)
http://www.ncbi.nlm.nih.gov/pubmed/10644463

Homocysteine had a mitogenic effect on vascular SMCs and a cytotoxic effect on endothelial cells. This differential effect of homocysteine on vascular cells may represent a pathogenic mechanism of vascular lesion formation in patients with hyperhomocysteinemia.
http://www.ncbi.nlm.nih.gov/pubmed/10699963

Regardless of the signaling pathways involved, homocysteine, by virtue of its role on VSMC proliferation and ECM deposition, has the potential to affect vascular reactivity.

http://circ.ahajournals.org/content/99/9/1230.full.pdf

Conclusions—Homocysteine enhances NO synthesis in IL-1b–stimulated VSMCs, and oxidative products are involved in
the effect of homocysteine
http://en.wikipedia.org/wiki/Homocysteine

Homocysteine [IPA: ˌhəʊməʊˈsɪstiːn] is a non-protein amino acid with the formula HSCH2CH2CH(NH2)CO2H. It is a homologue of the amino acid cysteine, differing by an additional methylene (-CH2-) group. It is biosynthesized from methionine by the removal of its terminal Cε methyl group. Homocysteine can be recycled into methionine or converted into cysteine with the aid of B-vitamins.
Increased levels of homocysteine are linked to high concentrations of endothelial asymmetric dimethylarginine. Recent research suggests that intense, long duration exercise raises plasma homocysteine levels, perhaps by increasing the load on methionine metabolism.
Homocysteine is not obtained from the diet.[28] Instead, it is biosynthesized from methionine via a multi-step process
http://en.wikipedia.org/wiki/Methionine (we had this earlier somewhere on page 1 think)

---- Now I need to let this digest for some time. Please feel free to add any ideas.

doublelongdaddy
07-30-12, 03:14 PM
That is some serious siting! Good work!

dickerschwanz
08-01-12, 06:51 PM
Serraptase

doesnt mix very good after 3 days. Added a capsule serraptase and it was better consistense. My DMSO in in the +6 freezer is frozen(go figure).
So I shaked it and thought why not heat it(as it had a hot reaction when mixing initaly). It reacted again.. bubbled kind of. Hard to take it out of the eyeglassdropper. Constitution was that of a cream.
Dont know if it penetrated still. But I feel good after clamping the application off(after edging).

Should break up the scarring in the dick.(It would be kind of measurable as I can feel the thick tunica pieces.)

Serraptase mixed priot to application with dmso seems wise. or at least every day some additional serraptase and dmso to refreshen it.

sizerp
08-06-12, 03:25 AM
You kind of got side-tracked there when you started researching androgen pathways and 5-AR inhibitors. We need DHT and E2 for sexual upregulation as well as musclular hypertrophy! Remember, you won't be able to cause permanent growth in smooth muscle directly. In order to cause hyperplasia you'll need exogenous HGH of some sort (IMO).

However, properly filled back-pathways of all other important hormones produced in the adrenal zonas is important as well. I think supplementing with DHEA and Pregnenolone at 100-200mg a day would be a good starting point if that's a concern. That aside, I'd love to see more info on DMSO and prevention of collagen overexpression and promotion of cell communication and regeneration.

dickerschwanz
08-06-12, 09:31 AM
You kind of got side-tracked there when you started researching androgen pathways and 5-AR inhibitors. We need DHT and E2 for sexual upregulation as well as musclular hypertrophy! Remember, you won't be able to cause permanent growth in smooth muscle directly. In order to cause hyperplasia you'll need exogenous HGH of some sort (IMO).

However, properly filled back-pathways of all other important hormones produced in the adrenal zonas is important as well. I think supplementing with DHEA and Pregnenolone at 100-200mg a day would be a good starting point if that's a concern. That aside, I'd love to see more info on DMSO and prevention of collagen overexpression and promotion of cell communication and regeneration.

Thanks for the side track info. Thats what I needed.
---
Yeah thats what I try to figure out. To push all pathways. I kind of think that starting at the rawest(lowest) part of the pathway with supplements is wise.
Then look what happens and maybe climb higher on the pathways(with the supplementing). Im really paranoid of supplementing the end product directly as I for sure dont want to disturb healthy pathways.

I will continue this research. Tough I got further then my mind could comprehend.. ;)

sizerp
08-07-12, 02:17 AM
Thanks for the side track info. Thats what I needed.
---
Yeah thats what I try to figure out. To push all pathways. I kind of think that starting at the rawest(lowest) part of the pathway with supplements is wise.
Then look what happens and maybe climb higher on the pathways(with the supplementing). Im really paranoid of supplementing the end product directly as I for sure dont want to disturb healthy pathways.

I will continue this research. Tough I got further then my mind could comprehend.. ;)

Haha yeah I hear ya. I sometimes wish we could process information at modern technological speeds. Maybe one day!

You could look into PT-141 maybe for a "workaround" to stimulating chronic, 150% erection status, through nervous system impulse, rather than focusing on adrenal steroid synthesis.

Nshawn9
11-24-12, 02:16 AM
What ratio do you use the DMSO and Iodine? i have some thick tissue on the dorsal part of my penis and this sounds like it could help.

Where do you find DMSO and Iodine, by the way?

Seun
11-24-12, 07:53 AM
Can i use DMSO cream instead of the liquid.

dickerschwanz
11-28-12, 06:54 PM
Can i use DMSO cream instead of the liquid.

Better the liquid. the 70% one.



What ratio do you use the DMSO and Iodine? i have some thick tissue on the dorsal part of my penis and this sounds like it could help.

Where do you find DMSO and Iodine, by the way?

50/50 most time but I have also more dmso and more iodine ratios. not sure which is best.
I bought it in germany. you have to search the net.

I did include Paba into my regimen and I think it does help even more.

Nshawn9
11-30-12, 10:39 PM
I did include Paba into my regimen and I think it does help even more.

Is PABA taken orally?

grapeape
04-13-14, 04:23 PM
This is an excellent thread.

Forgive my lack of knowledge wether they are lighter than DMSO, but has anyone tried creative or glutamine with the DMSO?