dickerschwanz;494715 said:
DMSO + smooth muscle research:

http://www.ncbi.nlm.nih.gov/puBathmateed/21967314

Effects of icariin on improving erectile function in streptozotocin-induced diabetic rats.

http://en.wikipedia.org/wiki/Icariin
( The compound is derived from several species of plants in the Epimedium family, which are commonly known as Horny Goat Weed or Yin Yang Huo.[)

->"Untreated diabetic animals had decreased smooth muscle/collagen ratio and endothelial cell content in the corpora cavernosa; treatment with icariin partially attenuating these effects."
"Icariin treatment preserved penile hemodynamics, smooth muscle and endothelial integrity, and neuronal nitric oxide synthase expression in the penis of diabetic rats."

DMSO in- creased the response of the smooth muscle of the stomach to both muscle and nerve stimulations.
(http://onlinelibrary.wiley.com/doi/10.1111/j.1749-6632.1967.tb34885.x/abstract)

Which in turn might mean that DMSO helps when training the smooth msucles.
I think that the DMSO wont be forever in the tissue so influence on the inhibition of smooth muscle proliferation(growth) might not be present after the dmso is gone.
 
How would it effect smooth muscle? That is where I am stuck???
 
doublelongdaddy;494743 said:
How would it effect smooth muscle? That is where I am stuck???
Me too.

wow anyone ever got a big post destroyed by a automatic windows update?
Whatever

http://en.wikipedia.org/wiki/Smooth_muscle_tissue

In short: DMSO pushes the smooth muscle to "grow" or "make ready" stuff that is contractory (actin) muscle cell stuff. The contractory stuff is in ratio 2:1 to 10:1 found(ratio towards myosin, the opposite in smooth muscle tissue). While it is kind of fixed with other muscles.
This is cause of http://en.wikipedia.org/wiki/Hyperplasia Hyperplasia. Smooth muscles divides into new smooth muscle while other muscles just expand.

This might be a problem as the penis needs to relax to fill with blood. So a too high ratio might give problems there.
On the other hand I guess everyone coudl be capable of pushing enough blood/relaxation into the dick via reverse kegels.

A smooth muscle is excited by external stimuli, which causes contraction
The contractile function of vascular smooth muscle also regulates the lumenal diameter of the small arteries-arterioles called resistance vessels, thereby contributing significantly to setting the level of blood pressure. Smooth muscle contracts slowly and may maintain the contraction (tonically) for prolonged periods in blood vessels, bronchioles, and some sphincters. Activating arteriole smooth muscle can decrease the lumenal diameter 1/3 of resting so it drastically alters blood flow and resistance. Activation of aortic smooth muscle doesn't significantly alter the lumenal diameter but serves to increase the viscoelasticity of the vascular wall.

Dont know what the conclusion from the above is but I think it describes what happens when there is more or less contractile stuff(which is pushed by DMSO) in the penis.
I think more contractory stuff means more power to hold blood inside. The relaxation or filling of the smooth muscles with blood can be done by kegels(reverse kegels) or other strong enough stimuli(woman, �naked people movies�).
Weak EQ might mean that smooth muscle is not "strong" enough. Tough, Im not sure about this..just trying to add 1+1..
Relaxation
The phosphorylation of the light chains by MLCK is countered by a myosin light-chain phosphatase, which dephosphorylates the MLC20 myosin light chains and thereby inhibits contraction.[2] Other signaling pathways have also been implicated in the regulation actin and myosin dynamics. In general, the relaxation of smooth muscle is by cell-signaling pathways that increase the myosin phosphatase activity, decrease the intracellular calcium levels, hyperpolarize the smooth muscle, and/or regulate actin and myosin dynamics.
Myosin is the opposite of Actin (the contractile stuff). Less Myosin light chains mean maybe less ability to relax?
the ratio can be anything between 2:1 and 10:2 while the ratio is kind of set with other muscles.

I think the ratio is very important.
Question is now:Which ratio gives most function and growth(diameter)? or does it really matter? And how is this connected to the kegel muscles.... checking tomorrow. open for any idea.

For me a good indicator is that contractory stuff(actin) is always in bigger ratio there(2:1 up to 10:2). So for the smooth muscle there is always more actin. So for me it makes sense that more actin means better smooth muscle.
But we need myosin to grow too so we have more room for the actin stuff to fill between the myosin chains.
 

Attachments

  • Actin_myosin_filaments.png
    Actin_myosin_filaments.png
    50.2 KB · Views: 2
Last edited:
Dicker. You might look over, " http://www.mattersofsize.com/forum/showthread.php?66865-IMPORTANT-Everyone-Should-Read-This!! " if you haven't already.
There are a few mentions of PABA/DMSO/MSM and there is also a preformulated product out there(think the link is on page 2).

The DMSO discussions are very interesting. Chempe/pegym/ & a few others have some decent discussions as well for anyone also interested(at least in terms of transdermal iodine/potaba).
 
thanks smerc. will look through it. yes there is already some stuff in Penis Enlargement community about dmso. Tough , its very scattered and anectodal and I would like to have it all nailed down which I hope this thread will help with.

________

Niacine + DMSO

Did found nothing about the combo (up to g page 5) but the flsuh effect should show if its possible...(tough there is a niacin without flush properties)

DMSO+Niacine+X flushed thorugh a clamped dick sounds like win.
Nicotinamide is soluable in DMSO!
http://www.tocris.com/dispprod.php?ItemId=280736#.UBXvqKM2eUk
 
Last edited:
There is a transdermal nitric oxide gel already called HFR that uses some proprietory solvent to pass through skin. I have tried it and it doesn't seem to get the nitric oxide to where you want it, i.e the muscle tissue of the penis. There are too much stuff under the skin for the stuff to work.
I was just wondering if insect venoms mixed with DMSO could be used for localized swelling. If it doesn't kill you, it would be a blast if it did work even temporarily.
 
Last edited:
MikelB;494858 said:
There is a transdermal nitric oxide gel already called HFR that uses some proprietory solvent to pass through skin. I have tried it and it doesn't seem to get the nitric oxide to where you want it, i.e the muscle tissue of the penis. There are too much stuff under the skin for the stuff to work.
I was just wondering if insect venoms mixed with DMSO could be used for localized swelling. If it doesn't kill you, it would be a blast if it did work even temporarily.

The best solvent seems to be DMSO. The great thing is that DMSO itself has many beneficial effects.

Look at what I found:
http://www.ncbi.nlm.nih.gov/puBathmateed/9334655
RESULTS:
DMSO acutely increased reflex firing of pelvic nerve efferent axons, decreased bladder capacity and also increased neuronal c-fos expression in spinal cord regions that exhibit c-fos expression after chemical activation of capsaicin-sensitive bladder afferents. DMSO, like capsaicin, also directly released nitric oxide (NO) from both dissociated dorsal root ganglion neurons and from isolated strips of urinary bladder.
CONCLUSIONS:

These results suggest that DMSO induced stimulation of bladder afferent pathways and NO release from afferent neurons may be a reflection of the initial event in the desensitization of nociceptive pathways in the lower urinary tract (LUT).
DMSO itself pushes the penis and the bladder to release NO.

Capsaicin too:
http://www.earthclinic.com/CURES/erectile-dysfunction.html#CAYENNE
So it seems soluable in DMSO at least in the form of cayenne(lol)
Yeah it works alright! I read comments here and tried to pursued my sweet hubby to try cayenne although he despises anything hot... I suggested DMSO and cayenne applied directly to the big conductor... He reluctantly agreed. Train wreck! I over applied and sent him running for the shower! After I googled a solution... I offered milk and mayo to ease the pain... I felt awful... He may never try my home remedies again..... He came back to bed... Fully dressed in pjs... So I thought our night was over... Twenty minutes later he began to remove clothing... His and mine! I have never felt him so full of life!!!! He remained aroused throughout several posit$&?! This was challenging before cayenne... All I can say is thank you... The transfer of cayenne heat added lots of spice to the end of my evening too, I was ready for ice! Thanks to this great site!!!!!!!"

So I wouldnt do it cause this stuff burns sure like hell but maybe there is some capsaicin form that doesnt burn like cayenne.

L-Arginine is also a nitric oxide "pusher".
If your body is capable of producing the stuff on itself with the building blocks then this must be used first.
There are reports that using an final/endproduct that the body on itself produces will end up with decreased sensivity to it as the body stops producing it on itself.

Bee venom I would be carefull if you use too much as DMSO might distribute it into the whole body.. and how would you get that stuff in a measurable form?

Here they used Bee Venom together with DMSO
http://sBathmates.ccmu.edu.cn/extra/col1/1193047177.pdf
During the whole process of the experiments, a volume
of 50 Al saline containing 0.2 mg bee venom (BV), 50 Al
100% dimethyl sulfoxide (DMSO), and a single dose of
propofol (0.5 Ag of 99.99% 2, 6-diisopropyl phenol
dissolved in 50 Al DMSO) was subcutaneously injected
into the posterior surface of one hind paw, respectively
Tough I cant workout if the BV did do anything..
 
dickerschwanz;494866 said:
Bee venom


There are two things that increase the size of my penis by double, bee stings and horses:) Unfortunately the same thing happens to my lips and eyes:)
 
Carnitine / Lysine

http://www.mail-archive.com/silver-list@eskimo.com/msg109702.html

One protocol we have found to be particularly effective
is the employment of lysine (many use the ointment applied topically) taken at
approximately 300 mg daily, together with the topical use of a lysine/DMSO
solution. The favored (by us) solution strength is 20% DMSO (by volume) mixed
with a super-saturated solution of lysine......applied to the blisters

___________

lysine converts to carnitine in the presence of vitamin C. lysine is cheap, carnitine is expensive.
 
L-Citruline converts to -> L-arginine
I did not know that...cool. Kinda like how L-citrulline converts to L-arginine and increases plasma L-arginine levels 4 fold greater that L-arginine itself.
_________________
While L-arginine may increase NO Nitric Oxide short term, it
can also increase urea which can increase uric acid. L-citrulline can increase NO for a much longer period of time
apparently without increasing uric acid. A clinical study reported good results with men with ED using 1500 mg of
L-citrulline daily. L-citrulline seems to work better if combined or taken with malic acid.
____
coudlnt find any hint on L-citrulline together with dmso.

____________
DMSO destroys arginine while ongoing hydrolisis(probably smooth muscle hydrolosis is affected too, but we want hydrolisis anyway)
http://www.aaccnet.org/publications/cc/backissues/1973/Documents/Chem50_309.pdf
Hm dont know what this means now.

At least it seems to transport via DMSO:
http://www.sigmaaldrich.com/etc/med...Sheet/b4875pis.Par.0001.File.tmp/b4875pis.pdf
L-arginine 4-nitroanilide hydrochloride(tough this is a variation)
Storage/Stability
A solution in DMSO (containing a small portion of
ethanol) is stable for about one week at room
temperature.

This talks about L-glutamine, L-arginine, L-lysine in combination with DMSO:
http://scholarsresearchlibrary.com/APR-vol1-iss4/APR-2010-1-4-82-88.pdf

I dont understand the conclusion but it seems they all dissolve in DMSO.

Arginine:
http://www.ncbi.nlm.nih.gov/puBathmateed/8992957
Also not clear what happened with arginine here, for me at least.
___________________
Amino acids + DMSO:

Found this small mentioning:
http://dwb.unl.edu/Teacher/NSF/C08/C08Links/pps99.cryst.bbk.ac.uk/projects/gmocz/fluor.htm
*DMSO = dimethyl sulfoxide, an organic solvent for amino acids and peptides.
-> sounds good for dmso in general in relation to amino acids and peptides(some of the stuff we want to transport is in this range)
_____________
This sounds promising:
Good stuff-must read:

https://data.epo.org/publication-server/getpdf.jsp?pn=2324838&ki=A1&cc=EP
In one embodiment, the invention comprises
the use of a composition comprising dimethylsulfoxide
(DMSO) in the preparation of a medication for the treatment
of stroke or brain injury, wherein said composition
additionally comprises one or more of the following: Larginine
and urea. About 1.0 to 8.0 grams of L-arginine
may be dissolved in a DMSO solution. DMSO may be
provided in a concentration of about 20% to about 40%.
In one embodiment, a dose of 70 grams of DMSO is used.
About 20% to about 60% urea can be used. In one embodiment,
a combination (e.g., a solution) of about 50%
DMSO and 50% urea is provided.
+
Together, DMSO and arginine may
have a combined, additive, or synergistic effect. In some
embodiments, DMSO and arginine (or NO) act on different
receptors or pathways to increase blood flow more
than either of the compounds administered alone. In other
embodiments, DMSO and arginine (or NO) act on the
same receptors or pathways to increase blood flow.
+
In other embodiments, DMS and L-arginine
are provided along with one or more of the following:
fructose 1,6-diphosphate, L-lysine, L-aspartate, urea,
DMSO, MSM, and other DMSO metabolites.
+Because arginine is the immediate precursor of
NO, urea, ornithine and agmatine, in some embodiments,
NO, urea, ornithine and agmatine are used in addition to
or instead of L-arginine in several of the compositions
described herein. Because arginine is synthesized from
citrulline, citrulline may be used in addition to or instead
of L-arginine in several of the compositions described
herein. Other forms of arginine, other than the L isomer
may also be used. The compositions described herein
may comprise nitric oxide synthase to facilitate the production
of NO from arginine.
+
As discussed above, L-arginine given as a continuous
intravenous infusion was able to reduce the levels
of endothelin-1, one of the most powerful vasoconstrictors
known and also lowered the serum levels of
asymmetric dimethylarginine (ADMA), an endogenous
inhibitor of eNOS. L-arginine combined with L-aspartate
or L-lysine can increase its peak levels in physiological
conditions such as an increase in growth hormones and
bone metabolism. It is therefore anticipated that the addition
of L-lysine and /or L-aspartate to L-arginine should
increase the efficacy of this amino acid in traumatic or
degenerative brain conditions, according to several embodiments
of the invention.
+
In one embodiment, the present invention comprises
a composition comprising DMSO and L-arginine,
DMSO and urea, or DMSO, L-arginine, and urea. In other
embodiments, the present invention comprises a composition
comprising DMSO, L-arginine, and additional
compound selected from the group consisting of one or
more of the following: fructose 1,6-diphosphate, L-lysine,
L-aspartate, and urea. In one embodiment, a synergistic
effect is obtained when DSMO and L-arginine are combined
with these additional compounds.
+In another embodiment, the invention comprises
a DMSO solution and one or more of the following: Larginine,
fructose 1,6-diphosphate, L-lysine, L-aspartate,
and urea. In one embodiment, a synergistic effect
is obtained when DSMO is combined with these additional
compounds. In one embodiment, about 200 to 900
mg of L-lysine is dissolved in (or otherwise combined
with) the DMSO solution. In another embodiment, about
100 to 1,200 mg of the L-aspartate is dissolved in (or
otherwise combined with) the DMSO solution.
+
In one embodiment, the invention provides a
pharmaceutical formulation comprising DMSO, L-arginine,
and L-lysine. In one embodiment, the invention
comprises a pharmaceutical formulation comprising DMSO
and L-lysine. In another embodiment, one or more
additional amino acids are included.

Make sure to check the picture at page 11/17 it shows how proliferation is done in the body..
http://www.faqs.org/patents/imgfull/20090312273_01 <- same picture
-> So this product, which I assume had some testing, clearly states arginine is applicable in DMSO.
Not only arginine but also other susbtances that may help in increasing penis size. In the above study it is talked about the influence on the brain. Tough at elast we know now that dmso can be combined with other substances what in turn can also increase the effect.
http://www.faqs.org/patents/app/20090312273 <- also good summary of the above.

This is done by a guy named De la Torre, Jack. He has soem stuff i nthe ent about DMSO so I guess he knows what he is talking about.
http://www.lef.org/magazine/mag2007/jul2007_cover_dmso_01.htm
<.great article

___
I think this all sounds promising.
Give the body the nutrients necessary for the cycle to complete. Smaller amounts are possible through the use of DMSO as it doesnt need to survive the stomach. Questions are now on where to apply? Is the whole cycle (http://www.faqs.org/patents/imgfull/20090312273_01) happening directly in the penis?
If so then applying dmso with the building blocks for errections and growth in combination with exercise is very easy.

I think applying the stuff directly to the dick and maybe clamping it off to let it concentrate i nthe dick localy might sounds promising. There are more substances to check for. And then once we have a good index we need to think about in which concentrations, when and how often to apply it.
Some stuff might be best for recovery for the night or rest days while some might aid with the exercises directly.
 
Last edited:
Fiansteride(in relation to producing DHT naturaly):
http://en.wikipedia.org/wiki/Finasterid
soluable in DMSO.
Would be interesting to find out non prescription/natural product that does similar stuff.
Basicly it is this stuff:
http://en.wikipedia.org/wiki/5α-reductase
Finasteride is synthesized from progesterone:
http://en.wikipedia.org/wiki/Progesterone


"An additional source of progesterone is milk products. After consumption of milk products the level of bioavailable progesterone goes up"
+
"In at least one plant, Juglans regia, progesterone has been detected.[7] In addition, progesterone-like steroids are found in Dioscorea mexicana. Dioscorea mexicana is a plant that is part of the yam family native to Mexico.[8] It contains a steroid called diosgenin that is taken from the plant and is converted into progesterone.[9] Diosgenin and progesterone are found in other Dioscorea species as well.

Another plant that contains substances readily convertible to progesterone is Dioscorea pseudojaponica native to Taiwan. Research has shown that the Taiwanese yam contains saponins &#8212; steroids that can be converted to diosgenin and thence to progesterone.[10]

Many other Dioscorea species of the yam family contain steroidal substances from which progesterone can be produced. Among the more notable of these are Dioscorea villosa and Dioscorea polygonoides. One study showed that the Dioscorea villosa contains 3.5% diosgenin.[11] Dioscorea polygonoides has been found to contain 2.64% diosgenin as shown by gas chromatography-mass spectrometry.[12] Many of the Dioscorea species that originate from the yam family grow in countries that have tropical and subtropical climates.[13]"
http://en.wikipedia.org/wiki/Progesterone#Biosynthesis
__
In mammals, progesterone (6), like all other steroid hormones, is synthesized from pregnenolone (3), which in turn is derived from cholesterol
http://en.wikipedia.org/wiki/Pregnenolone
also:
Progesterone in turn (see lower half of figure to the right) is the precursor of the mineralocorticoid aldosterone, and after conversion to 17-hydroxyprogesterone (another natural progestogen) of cortisol and androstenedione. Androstenedione can be converted to testosterone, estrone and estradiol.
->http://en.wikipedia.org/wiki/Aldosterone
->http://en.wikipedia.org/wiki/Aldosterone#Stimulation
<- interesting ->
"increase in plasma angiotensin II, ACTH, or potassium levels, which are present in proportion to plasma sodium deficiencies. (The increased potassium level works to regulate aldosterone synthesis by depolarizing the cells in the zona glomerulosa, which opens the voltage-dependent calcium channels.) The level of angiotensin II is regulated by angiotensin I, which is in turn regulated by the hormone renin. Potassium levels are the most sensitive stimulator of aldosterone."
Pottasium stimulates this stuff.
The plasma concentration of potassium
The amount of aldosterone secreted is a direct function of the serum potassium [12][13] as probably determined by sensors in the carotid artery.[
+
ACTH
ACTH, a pituitary peptide, also has some stimulating effect on aldosterone, probably by stimulating the formation of deoxycorticosterone, a precursor of aldosterone
ACTH is also related to the circadian rhytHydromax in many organisms. The half-life of ACTH in human blood is about ten minutes.
(it is produced mostly in the morning..maybe a little hint for a morning workout to use DHT?-> remember all this stuff is related to DHT production)

+
Aldosterone and corticosterone share the first part of their biosynthetic pathway
http://en.wikipedia.org/wiki/Corticosterone
One example of a release pathway relates to UV-B stimulation on the skins of certain amphibians such as the Rough-skinned Newt, Taricha granulosa; this trigger seems to cause the internal generation of corticosterone in that species. (NOTE:amphibians)
___________
This all seems cluttered till now all over the place but I have the feeling there are some connections and the picture of the puzzle will come through.
 
soem about smooth muscle
____________
Zinc + dmso
http://www.ncbi.nlm.nih.gov/puBathmateed/9397984
We previously showed that primary rat hepatocytes plated on a rat-tail collagen coated dish and fed a chemically-defined medium supplemented with 2% dimethylsulfoxide (DMSO) can be maintained in a well-differentiated, non-replicating state for periods of several months. In this study, we show that the addition of copper, iron, and zinc to the DMSO-containing chemically defined medium induced DNA synthesis and cell replication during the first two months in culture without loss of hepatic differentiation..
We conclude that under these specific nutritive conditions, primary rat hepatocytes proliferate and, with time, begin to form duct-like structures with altered gene expression and ultrastructural properties.
http://www.sciencedirect.com/science/article/pii/S0277538700869831
http://www.ingentaconnect.com/content/dav/aaua/1999/00000085/00000006/art00009
". The addition of electrolyte (zinc acetate) to aqueous solutions of nonelectrolyte (DMSO) do not destroy the structure created by an interaction: water-DMSO molecules"
http://researchspace.csir.co.za/dspace/bitstream/10204/4915/1/Du Plessis7_2010.pdf

http://www.chempap.org/file_access.php?file=403a323.pdf
->
Almost all our previous studies were concerned with nitrates as these are highly
soluble in both DMSO and water and give us a possibility to study the volumetric
and transport properties of solutions over the composition range in which the
number of particles of the electrolyte is comparable with that of solvent.
..
A comparison of highly concentrated solutions of ZnCl2 and Zn(N03)2 in
DMSO and water shows that the two electrolytes have opposite tendencies to
complexation and contact ion pair formation in DMSO and H20 solutions.
-> dont knwo what this indicates. Tough there seem to be different reaction to DMSO in the different forms of one supplement(in this case zinc)
-> So we also need to find out which form of the supplement is best use..

another info about zinc:
Zinc,[5] azelaic acid,[5] ?-sitosterol,[6] certain unsaturated aliphatic fatty acids such as gamma-linolenic acid, alpha-linolenic acid, linoleic acid, and oleic acid,[7] and a variety of polyphenols[8] have been found to inhibit 5?-reductase activity
http://en.wikipedia.org/wiki/5-alpha-reductase_inhibitor
http://en.wikipedia.org/wiki/5-alpha-reductase_inhibitor#Herbs Hydromax:
5-alpha-reductase inhibitors such as finasteride (brand names Proscar and Propecia), dutasteride (brand name Avodart), bexlosteride,izonsteride, turosteride, and epristeride are antiandrogenic as they prevent the reduction of testosterone to dihydrotestosterone (DHT).[16]DHT is 3-5 times more potent than testosterone or other androgens (except in skeletal muscle tissue, where testosterone is the main androgen). They are unique because they do not counteract the effects or production of other androgens other than DHT. Dihydrotestosterone is necessary for development of both external male sex organs and the prostate.
http://en.wikipedia.org/wiki/Antiandrogen
<-So we want to avoid that stuff!
http://en.wikipedia.org/wiki/Androgen
Muscle mass
Males typically have more skeletal muscle mass than females. Androgens promote the enlargement of skeletal muscle cells and probably act in a coordinated manner to function by acting on several cell types in skeletal muscle tissue.[4] One type of cell that conveys hormone signals to generating muscle is the myoblast. Higher androgen levels lead to increased expression of androgen receptor. Fusion of myoblasts generates myotubes, in a process that is linked to androgen receptor levels.[5]
myotubes(!) we had that earlier in the smooth muscle research I think.
http://en.wikipedia.org/wiki/Myoblasts
Each myocyte contains myofibrils, which are very long chains of sarcomeres, the contractile units of the cell. A cell from the biceps brachii muscle may contain 100,000 sarcomeres.[3] The myofibrils of smooth muscle cells are not arranged into sarcomeres. The sarcomeres are composed of thin and thick filaments. Thin filaments are actin filaments, whereas thick filaments consist of an arrangement of myosin proteins. The sarcomere does not contain organelles or a nucleus. Individual muscle fibrils are surrounded by endomysium.
-> actin + myosin which are the two building blocks of smooth muscle.
 
smooth muscle research:
Interleukin 6
http://en.wikipedia.org/wiki/Interleukin-6
-6 is also a "myokine," a cytokine produced from muscle, and is elevated in response to muscle contraction.[3] It is significantly elevated with exercise, and precedes the appearance of other cytokines in the circulation. During exercise, it is thought to act in a hormone-like manner to mobilize extracellular substrates and/or augment substrate delivery
Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine
-> means muscle work produces interleukin 6.(this might give also some reason for Penis Enlargement after exercise)
http://ajpheart.physiology.org/content/260/5/H1713.abstract
We have investigated the effect of interleukin 6 (IL-6) on the growth of vascular smooth muscle cells (VSMC) isolated from rat aortas.
These results support the premise that IL-6 is released by VSMC in an autocrine manner and promotes the growth of VSMC via induction of endogenous PDGF production.
Smooth msucle growth inhibition(to avoid)
http://ajpcell.physiology.org/content/267/5/C1405.abstract
Recent studies indicate that nitric oxide (NO) and guanosine 3',5'-cyclic monophosphate (cGMP) may inhibit the proliferation of vascular smooth muscle cells (SMC) in vitro.
AS already in a previous psot seen, there might be some correlation with NO and smooth muscle which inhibts growth(which might give indicators when to use nitric oxide)

__________
homocystein and smooth msucle growth:
http://www.ncbi.nlm.nih.gov/puBathmateed/20857402
Homocysteine may accelerate progression of atherosclerotic lesions by promoting SMC (smooth muscle)proliferation.
(another indicator where something might be better used locally)
http://www.ncbi.nlm.nih.gov/puBathmateed/10644463
Homocysteine had a mitogenic effect on vascular SMCs and a cytotoxic effect on endothelial cells. This differential effect of homocysteine on vascular cells may represent a pathogenic mechanism of vascular lesion formation in patients with hyperhomocysteinemia.
http://www.ncbi.nlm.nih.gov/puBathmateed/10699963
Regardless of the signaling pathways involved, homocysteine, by virtue of its role on VSMC proliferation and ECM deposition, has the potential to affect vascular reactivity.

http://circ.ahajournals.org/content/99/9/1230.full.pdf
Conclusions&#8212;Homocysteine enhances NO synthesis in IL-1b&#8211;stimulated VSMCs, and oxidative products are involved in
the effect of homocysteine
http://en.wikipedia.org/wiki/Homocysteine
Homocysteine [IPA: &#716;h&#601;&#650;m&#601;&#650;&#712;s&#618;sti&#720;n] is a non-protein amino acid with the formula HSCH2CH2CH(NH2)CO2H. It is a homologue of the amino acid cysteine, differing by an additional methylene (-CH2-) group. It is biosynthesized from methionine by the removal of its terminal C&#949; methyl group. Homocysteine can be recycled into methionine or converted into cysteine with the aid of B-vitamins.
Increased levels of homocysteine are linked to high concentrations of endothelial asymmetric dimethylarginine. Recent research suggests that intense, long duration exercise raises plasma homocysteine levels, perhaps by increasing the load on methionine metabolism.
Homocysteine is not obtained from the diet.[28] Instead, it is biosynthesized from methionine via a multi-step process
http://en.wikipedia.org/wiki/Methionine (we had this earlier somewhere on page 1 think)

---- Now I need to let this digest for some time. Please feel free to add any ideas.
 
That is some serious siting! Good work!
 
Serraptase

doesnt mix very good after 3 days. Added a capsule serraptase and it was better consistense. My DMSO in in the +6° freezer is frozen(go figure).
So I shaked it and thought why not heat it(as it had a hot reaction when mixing initaly). It reacted again.. bubbled kind of. Hard to take it out of the eyeglassdropper. Constitution was that of a cream.
Dont know if it penetrated still. But I feel good after clamping the application off(after edging).

Should break up the scarring in the dick.(It would be kind of measurable as I can feel the thick tunica pieces.)

Serraptase mixed priot to application with dmso seems wise. or at least every day some additional serraptase and dmso to refreshen it.
 
You kind of got side-tracked there when you started researching androgen pathways and 5-AR inhibitors. We need DHT and E2 for sexual upregulation as well as musclular hypertrophy! Remember, you won't be able to cause permanent growth in smooth muscle directly. In order to cause hyperplasia you'll need exogenous HGH of some sort (IMO).

However, properly filled back-pathways of all other important hormones produced in the adrenal zonas is important as well. I think supplementing with DHEA and Pregnenolone at 100-200mg a day would be a good starting point if that's a concern. That aside, I'd love to see more info on DMSO and prevention of collagen overexpression and promotion of cell communication and regeneration.
 
sizerp;495961 said:
You kind of got side-tracked there when you started researching androgen pathways and 5-AR inhibitors. We need DHT and E2 for sexual upregulation as well as musclular hypertrophy! Remember, you won't be able to cause permanent growth in smooth muscle directly. In order to cause hyperplasia you'll need exogenous HGH of some sort (IMO).

However, properly filled back-pathways of all other important hormones produced in the adrenal zonas is important as well. I think supplementing with DHEA and Pregnenolone at 100-200mg a day would be a good starting point if that's a concern. That aside, I'd love to see more info on DMSO and prevention of collagen overexpression and promotion of cell communication and regeneration.

Thanks for the side track info. Thats what I needed.
---
Yeah thats what I try to figure out. To push all pathways. I kind of think that starting at the rawest(lowest) part of the pathway with supplements is wise.
Then look what happens and maybe climb higher on the pathways(with the supplementing). Im really paranoid of supplementing the end product directly as I for sure dont want to disturb healthy pathways.

I will continue this research. Tough I got further then my mind could comprehend.. ;)
 
dickerschwanz;495981 said:
Thanks for the side track info. Thats what I needed.
---
Yeah thats what I try to figure out. To push all pathways. I kind of think that starting at the rawest(lowest) part of the pathway with supplements is wise.
Then look what happens and maybe climb higher on the pathways(with the supplementing). Im really paranoid of supplementing the end product directly as I for sure dont want to disturb healthy pathways.

I will continue this research. Tough I got further then my mind could comprehend.. ;)

Haha yeah I hear ya. I sometimes wish we could process information at modern technological speeds. Maybe one day!

You could look into PT-141 maybe for a "workaround" to stimulating chronic, 150% erection status, through nervous system impulse, rather than focusing on adrenal steroid synthesis.
 
What ratio do you use the DMSO and Iodine? i have some thick tissue on the dorsal part of my penis and this sounds like it could help.

Where do you find DMSO and Iodine, by the way?
 
Back
Top Bottom