While some people have reported positive effects from taking supplements like 5-HTP, zinc, and arginine for premature ejaculation, it's important to note that individual experiences may vary. It's always a good idea to consult with a healthcare professional or doctor before starting any new supplements, as they can provide personalized advice and guidance based on your specific situation. Additionally, there may be other factors contributing to premature ejaculation that could benefit from professional evaluation and treatment.